Evidence map›Paper›PMID 31280346›Full record

ArticleJournal of cancer research and clinical oncology2019

Co-expression network analysis identified candidate biomarkers in association with progression and prognosis of breast cancer.

Qiang Zhou, Jiangbo Ren, Jinxuan Hou, Gang Wang, Lingao Ju, Yu Xiao, Yan Gong

Open access · greenAbstract read
In one paragraph

Article in Journal of cancer research and clinical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 67 citations in OpenAlex.

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  11. Xiaotan Jieyu Prescription Alleviates Breast Precancerous Lesions through PI3K/Akt Signaling Pathway.Evidence-based complementary and alternative medicine : eCAM · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Qiang Zhou *Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Jiangbo Ren *Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, China.
Jinxuan HouDepartment of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
Gang WangDepartment of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, China.
Lingao JuDepartment of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, China.
Yu XiaoDepartment of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, China. yu.xiao@whu.edu.cn.
Yan GongDepartment of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, China. yan.gong@whu.edu.cn.ORCID http://orcid.org/0000-0002-4805-0459
Wuhan University · CN

Funding

Fundamental Research Funds for the Central Universities 2042018kf0065Health Commission of Hubei Province Scientific Research Project WJ2019Q047National Natural Science Foundation of China 81800429Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund znpy2017001Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund znpy2018028
6 · The paper itself

Abstract

purposeBreast cancer is one of the most common malignancies among females, and its prognosis is affected by a complex network of gene interactions. Weighted gene co-expression network analysis was used to construct free-scale gene co-expression networks and to identify potential biomarkers for breast cancer progression.

methodsThe gene expression profiles of GSE42568 were downloaded from the Gene Expression Omnibus database. RNA-sequencing data and clinical information of breast cancer from TCGA were used for validation.

resultsA total of ten modules were established by the average linkage hierarchical clustering. We identified 58 network hub genes in the significant module (R

conclusionsAGO2, CDC20, CDCA5, MCM10, MYBL2, and TTK were identified as candidate biomarkers for further basic and clinical research on breast cancer based on co-expression analysis.

Indexed as

Gene Regulatory NetworksTranscriptomeBiomarkers, TumorBreast NeoplasmsCluster AnalysisDisease ProgressionFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHigh-Throughput Screening AssaysHumansMicroarray AnalysisPrognosisBiomarkers, TumorBiomarkerBreast cancerGene Expression OmnibusPrognosisWeighted gene co-expression network analysis

Identifiers

PMID31280346
PMCPMC11810168
OpenAlexW2954434281

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.