ArticleAging2019
Lower hand grip strength in older adults with non-alcoholic fatty liver disease: a nationwide population-based study.
Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Association between grip strength and non-alcoholic fatty liver disease: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- MASLD in the oldest-old: lack of association with cognition or functional autonomy and poor predictive utility of the hepatic steatosis index.GeroScience · 2026Observational
- Article
- Possible association between metabolic dysfunction-associated steatotic liver disease predictors and hand grip strength.Scientific reports · 2025Article
- Clinical Characteristics of Sarcopenia in Nonalcoholic Fatty Liver Disease: A Systemic Scoping Review.Obesity facts · 2025Article
- Association of muscle mass, grip strength and fat-to-muscle ratio and metabolic dysfunction-associated steatotic liver disease in a middle-to-elderly aged population.Annals of medicine · 2024Article
- Muscle strength and non-alcoholic fatty liver disease/metabolic-associated fatty liver disease.World journal of gastroenterology · 2024Article
- Change in skeletal muscle mass is associated with hepatic steatosis in nonalcoholic fatty liver disease.Scientific reports · 2023Article
- Osteosarcopenia in NAFLD/MAFLD: An Underappreciated Clinical Problem in Chronic Liver Disease.International journal of molecular sciences · 2023Review
- Association between arthritis and hand grip strength indices combined with anthropometry in an older Korean population.PloS one · 2023Article
- Prevalence of sarcopenia using different methods in patients with non-alcoholic fatty liver disease.World journal of hepatology · 2022Article
- Interactions of physical activity, muscular fitness, adiposity, and genetic risk for NAFLD.Hepatology communications · 2022Article
- Review
- The relationship between dietary patterns and grip strength in the general population: the TCLSIH cohort study.European journal of nutrition · 2021Article
- Cancer Survivors with Low Hand Grip Strength Have Decreased Quality of Life Compared with Healthy Controls: The Korea National Health and Nutrition Examination Survey 2014-2017.Korean journal of family medicine · 2021Article
- Impact of exercise training on the sarcopenia criteria in non-alcoholic fatty liver disease: a systematic review and meta-analysis.European journal of translational myology · 2021Article
- Sarcopenia is associated with the presence of nonalcoholic fatty liver disease in Zhejiang Province, China: a cross-sectional observational study.BMC geriatrics · 2021Observational
- Association between grip strength and anthropometric characteristics in the community-dwelling elderly population in Taiwan.PloS one · 2021Article
- Longitudinal Associations Between Hand Grip Strength and Non-Alcoholic Fatty Liver Disease in Adults: A Prospective Cohort Study.Frontiers in medicine · 2021Article
- Association between Cardiorespiratory Fitness, Relative Grip Strength with Non-Alcoholic Fatty Liver Disease.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although both liver and muscle are metabolically active endocrine organs, and non-alcoholic fatty liver disease (NAFLD) and sarcopenia may share common pathogenic determinants, there have been few clinical studies of the relationship between NAFLD and muscle strength, especially in the elderly. We conducted a nationally representative population-based, cross-sectional study using data from the Korea National Health and Nutrition Examination Survey, which involved 1,897 men aged ≥50 years and 2,206 postmenopausal women. NAFLD was defined using the hepatic steatosis index (HSI) and low muscle strength was defined using the Korea-specific cut-off point of hand grip strength (HGS). Men and women with NAFLD had 7.3% and 7.9% lower HGS than controls, respectively. The odds ratios for low muscle strength in the presence of NAFLD were 2.51 in men and 2.34 in women. HSI inversely correlated with HGS in both men and women. Consistently, compared with men and women in the lowest HSI quartile, those in the highest quartile had 7.6% and 12.4% lower HGS, respectively, and were 5.63- and 3.58-times more likely to have low muscle strength, respectively. These results provide the first clinical evidence that NAFLD can be associated with muscular impairment in older adults, as demonstrated by lower muscle strength.
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