ArticleIn vivo (Athens, Greece)
Apigenin Exerts Anti-inflammatory Effects in an Experimental Model of Acute Pancreatitis by Down-regulating TNF-α.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Halodule uninervis ethanolic extract reduces inflammation in LPS-stimulated RAW 264.7 macrophages via NF-κB, STAT3, and MAPK modulation.Scientific reports · 2026Article
- Review
- Bioactive Compounds and their Therapeutic Potential in Gastrointestinal Disease.Current drug research reviews · 2026Review
- Alteration in oxidative stress markers and metabolic profile of the third instar larvae of transgenic drosophila exposed to apigenin and bis(2-ethylhexyl) phthalates.Toxicology research · 2025Article
- Apigenin mitigates intestinal barrier dysfunction in sepsis by modulating the AKT signaling pathway.BMC gastroenterology · 2025Article
- Article
- Apigenin Attenuates Hepatic Ischemia-Reperfusion-Induced Lung Injury via Downregulation of MMP-3 and MCP-1: An Experimental Study in Rats.Journal of clinical medicine · 2025Article
- Therapeutic potential of plant polyphenols in acute pancreatitis.Inflammopharmacology · 2025Review
- An overview of current research on the modulation of NLRP3 inflammasome by traditional Chinese medicine to combat acute pancreatitis.Frontiers in molecular biosciences · 2025Review
- Apigenin: A Bioflavonoid with a Promising Role in Disease Prevention and Treatment.Biomedicines · 2024Review
- Adipokines and their role in acute pancreatitis.Journal of medical biochemistry · 2024Article
- Regulatory Roles of Flavonoids in Caspase-11 Non-Canonical Inflammasome-Mediated Inflammatory Responses and Diseases.International journal of molecular sciences · 2023Review
- Apigenin ameliorates hepatic lipid accumulation by activating the autophagy-mitochondria pathway.Journal of food and drug analysis · 2021Article
- Article
- Network pharmacology-based analysis of Zukamu granules for the treatment of COVID-19.European journal of integrative medicine · 2021Article
- Effects of Serum Metabolites on the Pancreatic Transcriptome in Acute Acalculous Cholecystitis.Gastroenterology research and practice · 2021Article
- Effects of Apigenin Treatment on Random Skin Flap Survival in Rats.Frontiers in pharmacology · 2021Article
- Health-Promoting Effects ofAntioxidants (Basel, Switzerland) · 2020Review
- Article
- Recent insights into the biological functions of apigenin.EXCLI journal · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimThis study investigated the anti-inflammatory effect of apigenin in an experimental model of acute pancreatitis. Inflammatory response was reflected by tissue expression of the cytokine TNF-α coupled with histological examination. MATERIALS AND
methodsWistar rats were divided into three groups: Sham-group animals underwent laparotomy only, without any other interventions. Control-group animals underwent laparotomy and bilio-pancreatic duct ligation to induce pancreatitis without apigenin administration. Apigenin group animals were further treated with apigenin. Euthanasia was performed at 6, 12, 24, 48 and 72 h post-operatively.
resultsOver-expression of TNF-α in relation to postoperative time was observed in the control group (p<0.001). In the apigenin group, under-expression of TNF-α in relation to postoperative time was observed (p<0.013). At 72 h, apigenin reduced pancreatic TNF-α expression and prevented pancreatic necrosis.
conclusionApigenin slows progression and reduces severity of acute pancreatitis. Apigenin may serve as an adjunct to a more successful therapeutic strategy in acute pancreatitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.