ArticleCell metabolism2019
Aerobic Plus Resistance Exercise in Obese Older Adults Improves Muscle Protein Synthesis and Preserves Myocellular Quality Despite Weight Loss.
Article in Cell metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
87 citing papers in PubMed, 10 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Comparative Effects of 12 Exercise Modalities on Body Mass Index and Body Fat Percentage in Youth With Overweight or Obesity: A Systematic Review and Network Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Effectiveness of Digital Health Interventions in Older Adults With Frailty and Sarcopenia: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2026Pooled it
- Persevering or quitting? A systematic review of adherence and dropout in nutrition and exercise interventions for sarcopenic obesity.Asia Pacific journal of clinical nutrition · 2026Pooled it
- Comparative effectiveness of exercise modalities and nutritional supplementation for sarcopenic obesity in older adults: a network meta-analysis based on randomized controlled trials.Frontiers in public health · 2026Pooled it
- Impact of resistance exercise on patients with chronic kidney disease.BMC nephrology · 2024Pooled it
- The effects of combined exercise training on glucose metabolism and inflammatory markers in sedentary adults: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Scientific landscape of oxidative stress in sarcopenia: from bibliometric analysis to hotspots review.Frontiers in medicine · 2024Pooled it
- Medical Nutrition Therapy Interventions Provided by Dietitians for Adult Overweight and Obesity Management: An Academy of Nutrition and Dietetics Evidence-Based Practice Guideline.Journal of the Academy of Nutrition and Dietetics · 2023Guideline
- Effect of Exercise Training on Body Composition and Inflammatory Cytokine Levels in Overweight and Obese Individuals: A Systematic Review and Network Meta-Analysis.Frontiers in immunology · 2022Pooled it
- International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines.The journal of nutrition, health & aging · 2021Guideline
- The Role of Insulin Sensitivity in Lean Mass Changes During Weight Loss With or Without Exercise.Obesity (Silver Spring, Md.) · 2025Trial
- Effect of aerobic or resistance exercise, or both on insulin secretion, ciliary neurotrophic factor, and insulin-like growth factor-1 in dieting older adults with obesity.Clinical nutrition (Edinburgh, Scotland) · 2025Trial
- Serum C-Terminal Agrin Fragment With Acute and Long-Term Exercise and Angiotensin II Type I Receptor Blockade.Journal of cachexia, sarcopenia and muscle · 2025Trial
- Testosterone Modulation of Muscle Transcriptomic Profile During Lifestyle Therapy in Older Men with Obesity and Hypogonadism.Journal of cachexia, sarcopenia and muscle · 2025Trial
- Testosterone plus lifestyle therapy improves skeletal muscle glycolysis in older men with obesity and hypogonadism.Frontiers in endocrinology · 2025Trial
- Effects of a 2-year exercise training on neuromuscular system health in older individuals with low muscle function.Journal of cachexia, sarcopenia and muscle · 2023Trial
- Lifestyle Intervention Strategy to Treat Diabetes in Older Adults: A Randomized Controlled Trial.Diabetes care · 2022Trial
- Effect of Aerobic or Resistance Exercise, or Both, on Intermuscular and Visceral Fat and Physical and Metabolic Function in Older Adults With Obesity While Dieting.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- Body Composition Changes after a Weight Loss Intervention: A 3-Year Follow-Up Study.Nutrients · 2021Trial
- Effects of Moderate Combined Resistance- and Aerobic-Exercise for 12 Weeks on Body Composition, Cardiometabolic Risk Factors, Blood Pressure, Arterial Stiffness, and Physical Functions, among Obese Older Men: A Pilot Study.International journal of environmental research and public health · 2020Trial
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
Anabolic resistance and impaired myocellular quality contribute to age-related sarcopenia, which exacerbates with obesity. Diet-induced muscle mass loss is attenuated by resistance or aerobic plus resistance exercise compared to aerobic exercise in obese elderly. We assessed chronic effects of weight loss plus different exercise modalities on muscle protein synthesis response to feeding and myocellular quality. Obese older adults were randomized to a weight-management program plus aerobic, resistance, or combined aerobic and resistance exercise or to control. Participants underwent vastus lateralis biopsies at baseline and 6 months. Muscle protein synthesis rate increased more in resistance and combined than in control. Autophagy mediators' expression decreased more in combined than in aerobic, which experienced a higher increase in inflammation and mitochondrial regulators' expression. In obese elderly, combined aerobic and resistance exercise is superior to either mode independently for improving muscle protein synthesis and myocellular quality, thereby maintaining muscle mass during weight-loss therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.