ReviewTrends in cognitive sciences2019
Lesion Studies in Contemporary Neuroscience.
Review in Trends in cognitive sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 2 syntheses or guidelines pooled it, 231 citations in OpenAlex.
- Reevaluating the role of the hippocampus in memory: A meta-analysis of neurotoxic lesion studies in nonhuman primates.Hippocampus · 2023Pooled it
- Right-sided brain lesions predominate among patients with lesional mania: evidence from a systematic review and pooled lesion analysis.Translational psychiatry · 2020Pooled it
- Evidence of Motor Skill Learning in Acute Stroke Patients Without Lesions to the Thalamus and Internal Capsule.Stroke · 2022Trial
- Transient perturbation of the left temporal cortex evokes plasticity-related reconfiguration of the lexical network.Human brain mapping · 2020Trial
- Convergence of TMS Sites and Lesion Locations Associated With Nicotine Addiction Improvement on a Common Brain Circuit.The American journal of psychiatry · 2026Article
- Supratentorial Brain Lesions in Unconscious Patients Map to a Common Human Brain Circuit.Annals of neurology · 2026Observational
- Using connectome-based predictive models to reveal the systems standardized tests and clinical symptoms are reflecting.Nature communications · 2026Article
- Medial temporal lobe lesions reduce visual working memory precision.Brain : a journal of neurology · 2026Article
- Article
- A scoping review of portable ultra-low-field MRI studies in patients with acquired brain injury: Past, present, and future.Neuroimage. Reports · 2026Review
- Brain-computer interfaces as a causal probe for scientific inquiry.Trends in cognitive sciences · 2026Review
- Lesion network mapping of focal injury-related aggression finds two distinct network injury patterns.Brain communications · 2026Article
- Primary auditory cortex activity during early retrieval supports later extinction learning.Neurobiology of learning and memory · 2025Article
- Understanding the mind-brain relationship through focal neurodegenerative pathology.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Measurement invariance of a general cognitive performance measure across 27 European countries and Israel.European journal of ageing · 2025Article
- Double dissociation of dynamic and static face perception provides causal evidence for a third visual pathway.Nature communications · 2025Article
- Identifying Transdiagnostic Aggression Networks: The Role of Lesion Studies.Biological psychiatry · 2025Article
- A right frontal network for analogical and deductive reasoning.Brain : a journal of neurology · 2025Article
- Transient DREADD Manipulation of the Dorsal Dentate Gyrus in Rats Impairs Initial Learning of Place-Outcome Associations.Hippocampus · 2025Article
- Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Studies of humans with focal brain damage and non-human animals with experimentally induced brain lesions have provided pivotal insights into the neural basis of behavior. As the repertoire of neural manipulation and recording techniques expands, the utility of studying permanent brain lesions bears re-examination. Studies on the effects of permanent lesions provide vital data about brain function that are distinct from those of reversible manipulations. Focusing on work carried out in humans and nonhuman primates, we address the inferential strengths and limitations of lesion studies, recent methodological developments, the integration of this approach with other methods, and the clinical and ecological relevance of this research. We argue that lesion studies are essential to the rigorous assessment of neuroscience theories.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.