Evidence map›Paper›PMID 31279615›Full record

Observational studyClinical nutrition (Edinburgh, Scotland)2020

Fried food consumption and risk of coronary artery disease: The Million Veteran Program.

Jacqueline P Honerlaw, Yuk-Lam Ho, Xuan-Mai T Nguyen, Kelly Cho, Jason L Vassy, David R Gagnon, Christopher J O'Donnell, J Michael Gaziano, Peter W F Wilson, Luc Djousse and 1 more

Abstract readObservational Study
In one paragraph

Observational study in Clinical nutrition (Edinburgh, Scotland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jacqueline P HonerlawMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA. Electronic address: Jacqueline.Honerlaw@va.gov.
Yuk-Lam HoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Xuan-Mai T NguyenMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Kelly ChoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Jason L VassyMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
David R GagnonMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Christopher J O'DonnellMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
J Michael GazianoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Peter W F WilsonAtlanta VA Medical Center, Decatur, GA, USA; Emory University Schools of Medicine and Public Health, Atlanta, GA, USA.
Luc DjousseMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
VA Million Veteran Program

Funding

Pragmatic randomized trial of polygenic risk scoring for common diseases in primary careR35HG010706 · NHGRI · HARVARD MEDICAL SCHOOL · PI VASSY, JASON L · 2019 to 2024
$2.6M
Red Blood Cell Omega-3 Fatty Acids and Coronary Artery DiseaseR21HL088081 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DJOUSSE, LUC · 2009 to 2010
$484k
Cardiovascular Disease Risk Factors, Prevalent Cardiovascular Disease, and Genetics in the Million Veteran ProgramI01BX003340 · VA · VETERANS HEALTH ADMINISTRATION · PI CHO, KELLY, WILSON, PETER WYMAN · 2017 to 2017
–
Cardiovascular Disease Risk Factors, Cardiovascular Disease Risk Prediction, and Genetics in the Million Veteran ProgramI01BX004821 · VA · VETERANS HEALTH ADMINISTRATION · PI PETER WYMAN WILSON · 2020 to 2026
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Prediction of CVD Risk in VeteransI01CX001025 · VA · VETERANS HEALTH ADMINISTRATION · PI CHO, KELLY, WILSON, PETER WYMAN · 2014 to 2025
–
BLRD VA I01 BX003340BLRD VA I01 BX004821CSRD VA I01 CX001025NHGRI NIH HHS R35 HG010706NHLBI NIH HHS R21 HL088081
6 · The paper itself

Abstract

introductionPrevious studies of the relationship between fried food consumption and coronary artery disease (CAD) have yielded conflicting results. We tested the hypothesis that frequent fried food consumption is associated with a higher risk of incident CAD events in Million Veteran Program (MVP) participants.

methodsVeterans Health Administration electronic health record data were linked to questionnaires completed at MVP enrollment. Self-reported fried food consumption at baseline was categorized: (<1, 1-3, 4-6 times per week or daily). The outcome of interest was non-fatal myocardial infarction or CAD events. We fitted a Cox regression model adjusting for age, sex, race, education, exercise, smoking and alcohol consumption.

resultsOf 154,663 MVP enrollees with survey data, mean age was 64 years and 90% were men. During a mean follow-up of approximately 3 years, there were 6,725 CAD events. There was a positive linear relationship between frequency of fried food consumption and risk of CAD (p for trend 0.0015). Multivariable adjusted hazard ratios (95% CI) were 1.0 (ref), 1.07 (1.01-1.13), 1.08 (1.01-1.16), and 1.14 (1.03-1.27) across consecutive increasing categories of fried food intake.

conclusionsIn a large national cohort of U.S. Veterans, fried food consumption has a positive, dose-dependent association with CAD.

Indexed as

Cohort StudiesCookingCoronary Artery DiseaseDietary Fats, UnsaturatedFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedRisk AssessmentSelf ReportSurveys and QuestionnairesUnited StatesVeteransDietary Fats, UnsaturatedCoronary artery diseaseNutritionPopulation science

Identifiers

PMID31279615
PMCPMC7042950

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.