ArticleCell chemical biology2019
Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation.
Article in Cell chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Biological Evaluation and Computational Modelling Studies onCurrent pharmaceutical design · 2025Article
- Heterologous expression of lasso peptides with apparent participation in the morphological development in Streptomyces.AMB Express · 2024Article
- Dye Degradation, Antimicrobial Activity, and Molecular Docking Analysis of Samarium-Grafted Carbon Nitride Doped-Bismuth Oxobromide Quantum Dots.Global challenges (Hoboken, NJ) · 2023Article
- Catalytic evaluation andRSC advances · 2023Article
- Enhancing the Antibiotic Production by Thermophilic Bacteria Isolated from Hot Spring Waters via Ethyl Methanesulfonate Mutagenesis.Antibiotics (Basel, Switzerland) · 2023Article
- La-Doped CeOACS omega · 2023Article
- Nb/Starch-Doped ZnO Nanostructures for Polluted Water Treatment and Antimicrobial Applications: Molecular Docking Analysis.ACS omega · 2022Article
- Genome-Wide Identification of the LexA-Mediated DNA Damage Response in Streptomyces venezuelae.Journal of bacteriology · 2022Article
- Effective Disposal of Methylene Blue and Bactericidal Benefits of Using GO-Doped MnOACS omega · 2021Article
- Prodiginines Postpone the Onset of Sporulation inAntibiotics (Basel, Switzerland) · 2020Article
- Nonpathogenic Bacteria as Targets in Antimicrobial High-Throughput Screening.Trends in microbiology · 2020Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Common approaches to antibiotic discovery include small-molecule screens for growth inhibition in target pathogens and screens for inhibitors of purified enzymes. These approaches have a shared intent of seeking to directly target a vital Achilles heel in a pathogen of interest. Here, we report the first screen against a sporulation pathway in a non-pathogenic bacterium as a means of discovering novel antibiotics-this effort has resulted in two important discoveries. First, we show that the sporulation program of Streptomyces venezuelae is exquisitely sensitive to numerous forms of DNA damage. Second, we have identified a DNA gyrase inhibitor. This molecule, EN-7, is active against pathogenic species that are resistant to ciprofloxacin and other clinically important antibiotics. We suggest that this strategy could be applied to other morphogenetic pathways in prokaryotes or eukaryotes as a means of identifying novel chemical matter having scientific and clinical utility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.