ArticleDevelopmental cell2019
Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling.
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Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
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Who cites it
42 citing papers in PubMed, 112 citations in OpenAlex.
- Notch-hedgehog antagonism regulates stem cell niche formation through an E2-E3-E3 ubiquitin module.EMBO reports · 2026Article
- The nociceptor primary cilium.Brain : a journal of neurology · 2026Review
- Research progress on the Sonic Hedgehog signaling pathway in the central nervous system: Novel insights.Neural regeneration research · 2026Article
- Crosstalk between the circadian clock, intestinal stem cell niche, and epithelial cell fate decision.Genes & diseases · 2025Review
- GliFHV mice: a tool to investigate GLI processing and localization.Development (Cambridge, England) · 2025Article
- Phosphorylation-induced SUMOylation promotes Ulk4 condensation at the ciliary tip to transduce Hedgehog signal.Journal of cell science · 2025Article
- Article
- Hedgehog-stimulated phosphorylation at multiple sites activates Ci by altering Ci-Ci interfaces without full Suppressor of Fused dissociation.PLoS biology · 2025Article
- Regulatory mechanisms governing GLI proteins in hedgehog signaling.Anatomical science international · 2025Review
- Physiological analysis of the mechanism of Ci transcription factor activation through multiple Fused phosphorylation sites in Hedgehog signal transduction.bioRxiv : the preprint server for biology · 2025Article
- Morphogen-induced kinase condensates transduce Hh signal by allosterically activating Gli.Science advances · 2025Article
- Cell-Based Assays to Study SUMOylation in Drosophila.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Tai/NCOA2 suppresses the Hedgehog pathway by directly targeting the transcription factor Ci/GLI.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Global and local functions of the Fused kinase ortholog CdaH in intracellular patterning in Tetrahymena.Journal of cell science · 2024Article
- Phosphorylation of human glioma-associated oncogene 1 on Ser937 regulates Sonic Hedgehog signaling in medulloblastoma.Nature communications · 2024Article
- Using explainable machine learning to uncover the kinase-substrate interaction landscape.Bioinformatics (Oxford, England) · 2024Article
- Serine/threonine kinase 36 induced epithelial-mesenchymal transition promotes docetaxel resistance in prostate cancer.Scientific reports · 2024Article
- Ulk4 promotes Shh signaling by regulating Stk36 ciliary localization and Gli2 phosphorylation.eLife · 2023Article
- Sonic Hedgehog Signaling Pathway: A Role in Pain Processing.Neurochemical research · 2023Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Yuhong HanDepartment of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
Bing WangDepartment of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
Yong Suk ChoDepartment of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
Jian ZhuDepartment of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA; Laboratory of Molecular Oncology, School of Laboratory Medicine, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Henan Province, Xinxiang 453003, China.
Jiang WuDepartment of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
Yongbin ChenKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Yunnan, Kunming 650223, China.
Jin JiangDepartment of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA. Electronic address: jin.jiang@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · USKunming Institute of Zoology · CN
Funding
Cell signaling in development and regenerationR35GM118063 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Jin Jiang · 2016 to 2026
$9.4MREGULATION OF HEDGEHOG SIGNALING IN DROSOPHILAR01GM061269 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI JIANG, JIN · 2000 to 2016
$4.2MRegulation of Hh/Ci signaling by Cos2 and its partnersR01GM067045 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI JIANG, JIN · 2003 to 2015
$4.0MRole of Brg1 in Activity-Induced Neuronal Gene Expression and Synaptic PlasticityR01NS096068 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI WU, JIANG · 2016 to 2020
$1.8MA Novel Non-Cell Autonomous Tumor Suppressor Function of H3K27me3 Demethylase UTX/Kdm6a in MedulloblastomaR21NS104596 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI WU, JIANG · 2017 to 2018
$446kNIGMS NIH HHS R01 GM061269NIGMS NIH HHS R01 GM067045NIGMS NIH HHS R35 GM118063NINDS NIH HHS R01 NS096068NINDS NIH HHS R21 NS104596
Abstract
Hedgehog (Hh) signaling culminates in the conversion of the latent transcription factor Cubitus interruptus (Ci)/Gli into its activator form (Ci
Indexed as
Signal Transduction3T3 CellsAnimalsAutophagy-Related Protein-1 HomologCell Line, TumorCells, CulturedDNA-Binding ProteinsDrosophila melanogasterDrosophila ProteinsHedgehog ProteinsHEK293 CellsHumansMicePhosphorylationProtein Serine-Threonine KinasesRepressor ProteinsAutophagy-Related Protein-1 Homologci protein, DrosophilaDNA-Binding ProteinsDrosophila Proteinsfu protein, DrosophilaHedgehog ProteinsProtein Serine-Threonine KinasesRepressor ProteinsSTK36 protein, humanSUFU protein, humanTranscription FactorsZinc Finger Protein Gli2CiFuGli2HedgehogmedulloblastomaShhSufuULK1ULK3
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.