Evidence map›Paper›PMID 31279488›Full record

ArticleNursing outlook

Precision medicine and health disparities: The case of pediatric acute lymphoblastic leukemia.

Wylie Burke, Kenneth Thummel

Open access · greenAbstract read
In one paragraph

Article in Nursing outlook. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Identifying caregiver-reported modifiable barriers to pediatric oncology clinical trial enrollment and participation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
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  6. Precision Nursing: advances and challenges in implementation.Revista latino-americana de enfermagem · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Wylie BurkeDepartment of Bioethics and Humanities, University of Washington, Seattle, WA. Electronic address: wburke@uw.edu.
Kenneth ThummelDepartment of Pharmaceutics, University of Washington, Seattle, WA.
University of Washington · US

Funding

Vitamin K gene network: Variant discovery and characterizationP01GM116691 · NIGMS · UNIVERSITY OF WASHINGTON · PI BURKE, WYLIE G., THUMMEL, KENNETH E. · 2016 to 2020
$7.6M
NIGMS NIH HHS P01 GM116691
6 · The paper itself

Abstract

backgroundPrecision medicine has uncertain potential to address population health disparities. PURPOSE: Case study of disparities in pediatric acute lymphoblastic leukemia (ALL).

methodLiterature-based evaluation of ALL in African American (AA) and European American (EA) children.

findingsAA children have a lower incidence of ALL than EA children, experience higher relapse rates, and are more likely to be diagnosed with poor prognostic indicators. Environmental risk exposures for ALL have small effect sizes; data are insufficient to determine their contribution to differences in incidence and prognosis. Differences in prevalence of gene variants associated with treatment response contribute to higher relapse rates in AA children. However, higher relapse rates were not seen in a care setting that eliminated out of pocket costs, used risk-directed therapy, and included rigorous case management. DISCUSSION: Unequal access to effective treatment contributes to ALL disparities. Precision medicine can help to define effective treatment for diverse patient populations.

Indexed as

AdolescentBlack or African AmericanChildChild, PreschoolFemaleHealthcare DisparitiesHispanic or LatinoHumansInfantInfant, NewbornMalePrecision MedicinePrecursor Cell Lymphoblastic Leukemia-LymphomaSocioeconomic FactorsTreatment OutcomeUnited StatesChildhood leukemiaHealth disparitiesPharmacogenomicsPrecision medicine

Identifiers

PMID31279488
PMCPMC6768085
OpenAlexW2945560200

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.