Evidence map›Paper›PMID 31279426›Full record

ReviewCardiology clinics2019

Apolipoprotein L1, Cardiovascular Disease and Hypertension: More Questions than Answers.

Niralee Patel, Girish N Nadkarni

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cardiology clinics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Niralee PatelDivision of Nephrology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029, USA.
Girish N NadkarniDivision of Nephrology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029, USA. Electronic address: girish.nadkarni@mountsinai.org.
Icahn School of Medicine at Mount Sinai · US

Funding

Elucidating Genetic and Environmental Second Hits in Racial and Ethnic Minorities with APOL1 High-Risk GenotypesR01DK127139 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI NADKARNI, GIRISH NITIN · 2021 to 2025
$4.0M
NIDDK NIH HHS R01 DK127139
6 · The paper itself

Abstract

Ethnic disparities in health outcomes exist among multiple complex diseases especially cardiovascular disease, hypertension, and kidney disease. Recent discoveries in genetics have taught us that these disparities go beyond environmental and socioeconomic factors. The discovery of ethnic-specific risk variants in the Apolipoprotein L1 (APOL1) gene on chromosome 22 seen only in individuals of recent African ancestry explains a large proportion of kidney disease disparities. In addition, recent large-scale genotype-phenotype association studies have identified associations with cardiovascular disease and hypertension. This review aims to review the recent literature in this field and point toward future directions for research.

Indexed as

MutationApolipoprotein L1Cardiovascular DiseasesDNAGenetic Predisposition to DiseaseHumansHypertensionRisk FactorsApolipoprotein L1DNACardiovascular diseaseHypertensionKidney disease

Identifiers

PMID31279426
PMCPMC10294128
OpenAlexW2945845419

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.