ArticleDiagnostic pathology2019
Primary endocervical gastric-type adenocarcinoma: a clinicopathologic and immunohistochemical analysis of 23 cases.
Article in Diagnostic pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- BRAP maintains SEC24D stability to regulate ER stress and promote cervical adenocarcinoma progression.Journal of translational medicine · 2026Article
- Clinicopathological characteristics and outcomes of gastric-type adenocarcinoma of the cervix: a systematic review.AJOG global reports · 2026Review
- Therapeutic strategy for cervical gastric-type adenocarcinoma by targeting CLU to relieve CLU-associated stress and sensitize chemotherapy.Precision clinical medicine · 2026Article
- Gastric-Type Cervical Adenocarcinoma: Clinicopathologic Features, Molecular Landscape, and Therapeutic Challenges.Journal of personalized medicine · 2026Review
- Molecular Features of HPV-Independent Cervical Cancers.Pathogens (Basel, Switzerland) · 2025Review
- Lobular Endocervical Glandular Hyperplasia and Related Glandular Disorders: Current Status of Diagnosis with MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Review
- Clinicopathologic characteristics and outcome of gastric-type endocervical adenocarcinoma: a single-center retrospective study.International journal of clinical and experimental pathology · 2025Article
- Novel ultrasound features and diagnostic clues of gastric-type endocervical adenocarcinoma: a case series.Frontiers in oncology · 2025Article
- Genetic variation at a splicing branch point in intron 7 of STK11: a rare variant decreasing its expression in a Chinese family with Peutz-Jeghers syndrome.World journal of surgical oncology · 2024Article
- Novel predictors for identifying cervical minimal deviation adenocarcinoma patients with poor prognosis: a long-term observational study in a tertiary centre.Archives of gynecology and obstetrics · 2024Observational
- Pattern of MUC6 expression across 119 different tumor types: A tissue microarray study on 15 412 tumors.Pathology international · 2023Article
- Extracellular vesicles, hyperadhesive von willebrand factor, and outcomes of gastric cancer: a clinical observational study.Medical oncology (Northwood, London, England) · 2023Observational
- Immunohistochemical and molecular analysis of an α-fetoprotein-producing cervical adenocarcinoma with clear cell morphology.Medical molecular morphology · 2023Article
- Article
- Cytopathologic features of human papillomavirus-independent, gastric-type endocervical adenocarcinoma.Journal of pathology and translational medicine · 2022Article
- Case Report: Gastric-Type Endocervical Adenocarcinoma Mimicking Submucosal Myoma Under Hysteroscopy.Frontiers in medicine · 2022Article
- Gastric type adenocarcinoma of the cervix presenting as ovarian neoplasm.Gynecologic oncology reports · 2021Article
- A retrospective study on incidence, diagnosis, and clinical outcome of gastric-type endocervical adenocarcinoma in a single institution.Diagnostic pathology · 2021Article
- Cytomorphologic Features of Gastric-Type Endocervical Adenocarcinoma in Liquid-Based Preparations.Acta cytologica · 2021Article
- [Cytological findings in glandular lesions of the uterine cervix].Der Pathologe · 2020Review
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5 authors.
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Abstract
backgroundEndocervical gastric-type adenocarcinoma (GAS) is a rare non-human papillomavirus-associated adenocarcinoma (NHPVA) with morphologic and immunohistochemical features of gastric differentiation. This study aimed to evaluate cytologic and clinicopathological features, differential diagnosis of endocervical GAS.
methodsA total of 23 patients diagnosed with endocervical GAS/minimal deviation adenocarcinoma (MDA) at Peking University People's Hospital between 2009 and 2018 were included. Clinical characteristics, cytologic/histopathologic findings, and immunohistochemical results were collected and analyzed.
resultsThe average age of patients was 51 years old (range from 28 to 73). Cytologically, tall columnar epithelial cells with pale, foamy or vacuolated cytoplasm were mostly common, followed by well-defined cytoplasmic borders. Fourteen endocervical GAS cases demonstrated mild cytologic atypia, and 9 cases showed moderate to marked cytologic atypia. Ovarian and fallopian tube involvement were identified in 5 and 6 cases, respectively. Immunohistochemically, tumor cells were diffusely positive for CK7, MUC6 and CA-IX, but focally positive for CK20 and CDX2. P16 was negative or patchy positive in most cases and p53 mutation was identified in 12 cases (12/21, 57.1%).
conclusionsEndocervical GAS shows different morphologic and immunological features from endocervical usual type adenocarcinoma, but it may be difficult to be differentiated from metastatic mucinous adenocarcinoma to cervix due to similar morphology and overlapping immunohistochemical profile. Therefore, awareness of the morphologic features and immunohistochemical profile of GAS will allow pathologists to recognize and accurately diagnose this rare and aggressive entity.
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