Evidence map›Paper›PMID 31279091›Full record

ArticleFree radical biology & medicine2019

Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1α/AMPK/Sirt1/PGC-1α/UCP2 pathway in a rat model of neonatal HIE.

Juan Huang, Wei Liu, Desislava Met Doycheva, Marcin Gamdzyk, Weitian Lu, Jiping Tang, John H Zhang

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  12. Exogenous HSleep & breathing = Schlaf & Atmung · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Juan HuangInstitute of Neuroscience, Chongqing Medical University, Chongqing, 400016, China; Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, 92350, USA.
Wei LiuDepartment of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, 92350, USA; Department of Physiology, School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Desislava Met DoychevaDepartment of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, 92350, USA.
Marcin GamdzykDepartment of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, 92350, USA.
Weitian LuInstitute of Neuroscience, Chongqing Medical University, Chongqing, 400016, China; Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, 92350, USA.
Jiping TangDepartment of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, 92350, USA.
John H ZhangDepartment of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, 92350, USA; Department of Anesthesiology, Loma Linda University, Loma Linda, CA, 92350, USA; Department of Neurosurgery, Loma Linda University, Loma Linda, CA, 92350, USA. Electronic address: jhzhang@llu.edu.

Funding

ER stress and neonatal hypoxia ischemia encephalopathyR01NS104083 · NINDS · LOMA LINDA UNIVERSITY · PI ZHANG, JOHN H · 2018 to 2022
$1.7M
NINDS NIH HHS R01 NS104083
6 · The paper itself

Abstract

Neuronal apoptosis induced by oxidative stress is one of the major pathological processes involved in neurological impairment after hypoxic-ischemic encephalopathy (HIE). Ghrelin, the unique endogenous ligand for the growth hormone secretagogue receptor-1α (GHSR-1α), could take an anti-apoptotic role in the brain. However, whether ghrelin can attenuate neuronal apoptosis by attenuating oxidative stress after hypoxia-ischemia (HI) insult remains unknown. To investigate the beneficial effects of ghrelin on oxidative stress injury and neuronal apoptosis induced by HI, ten-day old unsexed rat pups were subjected to HI injury and exogenous recombinant human ghrelin(rh-Ghrelin) was administered intranasally at 1 h and 24 h after HI induction. [D-Lys

Indexed as

AMP-Activated Protein Kinase KinasesAnimalsAnimals, NewbornApoptosisDisease Models, AnimalGhrelinHumansHypoxia-Ischemia, BrainNeuronsOxidative StressPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaProtein KinasesRatsReceptors, GhrelinSignal TransductionSirtuin 1AMP-Activated Protein Kinase KinasesGhrelinGhsr1a protein, ratPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, ratProtein KinasesReceptors, GhrelinSirt1 protein, ratSirtuin 1Ucp2 protein, ratUncoupling Protein 2GhrelinGHSR-1αHypoxic-ischemic encephalopathyNeuronal apoptosisOxidative stress

Identifiers

PMID31279091
PMCPMC6718314

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.