Evidence map›Paper›PMID 31279063›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2019

Interaction of blood plasma proteins with superhemophobic titania nanotube surfaces.

Roberta Maia Sabino, Kirsten Kauk, Sanli Movafaghi, Arun Kota, Ketul C Popat

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Roberta Maia SabinoSchool of Advanced Materials Discovery, Colorado State University, Fort Collins, CO, USA.
Kirsten KaukSchool of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA.
Sanli MovafaghiDepartment of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA.
Arun KotaSchool of Advanced Materials Discovery, Colorado State University, Fort Collins, CO, USA; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA; Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA.
Ketul C PopatSchool of Advanced Materials Discovery, Colorado State University, Fort Collins, CO, USA; School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA; Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA. Electronic address: ketul.popat@colostate.edu.
Colorado State University · US

Funding

Superhydrophobic Heart Valve ProsthesisR01HL135505 · NHLBI · OHIO STATE UNIVERSITY · PI DASI, LAKSHMI PRASAD, KOTA, ARUN KUMAR · 2017 to 2020
$2.9M
Superomniphobic flow controlled prosthetic heart valveR21HL139208 · NHLBI · OHIO STATE UNIVERSITY · PI DASI, LAKSHMI PRASAD, KOTA, ARUN KUMAR · 2018 to 2019
$408k
NHLBI NIH HHS R01 HL135505NHLBI NIH HHS R21 HL139208
6 · The paper itself

Abstract

The need to improve blood biocompatibility of medical devices is urgent. As soon as blood encounters a biomaterial implant, proteins adsorb on its surfaces, often leading to several complications such as thrombosis and failure of the device. Therefore, controlling protein adsorption plays a major role in developing hemocompatible materials. In this study, the interaction of key blood plasma proteins with superhemophobic titania nanotube substrates and the blood clotting responses was investigated. The substrate stability was evaluated and fibrinogen adsorption and thrombin formation from plasma were assessed using ELISA. Whole blood clotting kinetics was also investigated, and Factor XII activation on the substrates was characterized by an in vitro plasma coagulation time assay. The results show that superhemophobic titania nanotubes are stable and considerably decrease surface protein adsorption/Factor XII activation as well as delay the whole blood clotting, and thus can be a promising approach for designing blood contacting medical devices.

Indexed as

AdsorptionBiocompatible MaterialsBlood CoagulationBlood ProteinsEnzyme-Linked Immunosorbent AssayFactor XIIFibrinogenHumansKineticsNanotubesPlatelet AdhesivenessSurface PropertiesTitaniumBiocompatible MaterialsBlood ProteinsFactor XIIFibrinogenTitaniumtitanium dioxideFactor XIIFibrinogenHemocompatibilityProtein adsorptionSuperhemophobicTitania nanotubes

Identifiers

PMID31279063
PMCPMC6814547
OpenAlexW2954554928

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.