Evidence map›Paper›PMID 31278917›Full record

ArticleToxicology and applied pharmacology2019

TET1 regulates DNA repair in human glial cells.

Katherine J Kuhns, Hernando Lopez-Bertoni, Jonathan B Coulter, Joseph P Bressler

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology and applied pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Katherine J KuhnsEnvironmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Johns Hopkins School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Hernando Lopez-BertoniDepartment of Neurology, Hugo W. Moser Research Institute at Kennedy Krieger, 707 N. Broadway, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Jonathan B CoulterDepartment of Neurology, Hugo W. Moser Research Institute at Kennedy Krieger, 707 N. Broadway, Baltimore, MD 21205, USA; Environmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Johns Hopkins School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Joseph P BresslerDepartment of Neurology, Hugo W. Moser Research Institute at Kennedy Krieger, 707 N. Broadway, Baltimore, MD 21205, USA; Environmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Johns Hopkins School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA. Electronic address: bressler@kennedykrieger.org.
Kennedy Krieger Institute · USJohns Hopkins University · US

Funding

Traning Program in Environmental Health SciencesT32ES007141 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Marsha Wills-Karp · 1985 to 2026
$22.2M
NIEHS NIH HHS T32 ES007141
6 · The paper itself

Abstract

Glioblastomas are the most aggressive of malignant brain cancers with a median patient survival of approximately 18 months. We recently demonstrated that Tet methylcytosine dioxygenase 1(TET1) is involved in cellular responses to ionizing radiation (IR) in glial-, glioblastoma-, and non-tumor-derived cells. This study used a lentiviral-mediated knockdown of TET1 to further dissect the contribution of TET1 to the DNA damage response in glial cell lines by evaluating its role in DNA repair. TET1-deficient glial cell lines displayed attenuated cytotoxicity compared to non-targeted knockdown after treatment with IR but these differences were not observed between control and TET1 deficient in response to inhibitors of Na

Indexed as

DNA RepairNeurogliaRadiation, IonizingCell LineDNA DamageGliomaHumansMixed Function OxygenasesProto-Oncogene ProteinsMixed Function OxygenasesProto-Oncogene ProteinsTET1 protein, humanDNA-PKHuman gliomaIonizing radiationNon homologous DNA repairTET1

Identifiers

PMID31278917
PMCPMC7184935
OpenAlexW2953480483

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.