Evidence map›Paper›PMID 31278859›Full record

ArticleJournal of cellular and molecular medicine2019

Staphylococcus epidermidis role in the skin microenvironment.

Caroline Leonel, Isadora F G Sena, Walison N Silva, Pedro H D M Prazeres, Gabriel R Fernandes, Pamela Mancha Agresti, Mariana Martins Drumond, Akiva Mintz, Vasco A C Azevedo, Alexander Birbrair

Abstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Skin commensal bacteriumMicrobiology spectrum · 2026
    Article
  2. Skin and gut microbiome in atopic dermatitis: Mechanisms and therapeutic opportunities.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Review
  3. Review
  4. Article
  5. Microenvironmental host-microbe interactions in chronic inflammatory skin diseases.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2024
    Review
  6. Article
  7. Skin Deep: The Potential of Microbiome Cosmetics.Journal of microbiology (Seoul, Korea) · 2024
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Glioma Pericytes Promote Angiogenesis by Producing Periostin.Cellular and molecular neurobiology · 2022
    Review
  13. Prenylated phenolics fromFrontiers in pharmacology · 2022
    Article
  14. A Journey on the Skin Microbiome: Pitfalls and Opportunities.International journal of molecular sciences · 2021
    Review
  15. Article
  16. Review
  17. Review
  18. Sensory nerves in the spotlight of the stem cell niche.Stem cells translational medicine · 2021
    Review
  19. On the surface: Skin microbial exposure contributes to allergic disease.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2020
    Review
  20. Ablation of sensory nerves favours melanoma progression.Journal of cellular and molecular medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Caroline LeonelDepartamento de Patologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Isadora F G SenaDepartamento de Patologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Walison N SilvaDepartamento de Patologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Pedro H D M PrazeresDepartamento de Patologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Gabriel R FernandesOswaldo Cruz Foundation, René Rachou Research Center, Belo Horizonte, Brasil.
Pamela Mancha AgrestiDepartamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Mariana Martins DrumondDepartamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Akiva MintzDepartment of Radiology, Columbia University Medical Center, New York, New York.
Vasco A C AzevedoDepartamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Alexander BirbrairDepartamento de Patologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.ORCID 0000-0003-1015-2561

Funding

Therapeutically Exploiting a Newly Isolated Neural-Like Stem Cell Against GSBR01CA179072 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MINTZ, AKIVA · 2015 to 2020
$1.6M
NCI NIH HHS R01 CA179072
6 · The paper itself

Abstract

Wound healing is a complex dynamic physiological process in response to cutaneous destructive stimuli that aims to restore the cutaneous' barrier role. Deciphering the underlying mechanistic details that contribute to wound healing will create novel therapeutic strategies for skin repair. Recently, by using state-of-the-art technologies, it was revealed that the cutaneous microbiota interact with skin immune cells. Strikingly, commensal Staphylococcus epidermidis-induced CD8+ T cells induce re-epithelization of the skin after injury, accelerating wound closure. From a drug development perspective, the microbiota may provide new therapeutic candidate molecules to accelerate skin healing. Here, we summarize and evaluate recent advances in the understanding of the microbiota in the skin microenvironment.

Indexed as

AnimalsCD8-Positive T-LymphocytesCellular MicroenvironmentHumansMiceMicrobiotaSkinSkin NeoplasmsSkin Physiological PhenomenaStaphylococcus epidermidisWound Healingmicrobiotamicroenvironmentskinwound healing

Identifiers

PMID31278859
PMCPMC6714221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.