Evidence map›Paper›PMID 31278819›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020

The "oldest and coldest" shipped living donor kidneys transplanted through kidney paired donation.

Nima Nassiri, Lorna Kwan, Aswani Bolagani, Alvin G Thomas, Joseph Sinacore, Matthew Ronin, Matthew Cooper, Dorry L Segev, J Michael Cecka, Jeffrey L Veale

Abstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Navigating a Quandary in Kidney Exchange Programs: A Review of Donor Travel versus Organ Shipment.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
  6. Review
  7. Motivations and outcomes of compatible living donor-recipient pairs in paired exchange.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  8. Article
  9. Early graft losses in paired kidney exchange: Experience from 10 years of the National Kidney Registry.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nima NassiriInstitute of Urology, University of Southern California, Los Angeles, California.ORCID 0000-0003-3447-8013
Lorna KwanDepartment of Urology, University of California Los Angeles, Los Angeles, California.
Aswani BolaganiDepartment of Urology, University of California Los Angeles, Los Angeles, California.
Alvin G ThomasDepartment of Surgery, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0003-4911-8192
Joseph SinacoreNational Kidney Registry, Babylon, New York.
Matthew RoninNational Kidney Registry, Babylon, New York.
Matthew CooperMedstar Georgetown Transplant Institute, Washington, District of Columbia.
Dorry L SegevDepartment of Surgery, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0003-3205-1024
J Michael CeckaImmunogenetics Center, University of California Los Angeles, Los Angeles, California.
Jeffrey L VealeDepartment of Urology, University of California Los Angeles, Los Angeles, California.

Funding

Cardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wayne D. Rosamond · 1986 to 2026
$10.0M
Long-Term Health Outcomes After Live Kidney Donation in African AmericansR01DK096008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2013 to 2017
$3.8M
Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
NHLBI NIH HHS T32 HL007055NIAID NIH HHS K24 AI144954NIDDK NIH HHS K24 DK101828NIDDK NIH HHS R01 DK096008
6 · The paper itself

Abstract

To date, thousands of living donor kidneys have been shipped through kidney paired donation (KPD). To expand on this growing segment of living donor transplantation, we evaluated the effect of advanced age donation ("oldest kidneys") and prolonged cold ischemia time ("coldest kidneys") on graft function and survival using the National Kidney Registry database from February 2008 to May 2018. Donors were stratified by age at time of donation (<65 or ≥65 years) and kidneys were stratified by cold ischemia time (<16 or ≥16 hours). We evaluated delayed graft function and death-censored graft failure (DCGF) for up to seven posttransplant years. Of the 2363 shipped living donor kidney transplants, 4.1% of donors were ≥65 years and 6.0% of transplanted kidneys had cold ischemia times ≥16 hours. Delayed graft function and DCGF occurred in 5.2% and 4.7% of cases. There were no significant associations between delayed graft function and donor age (P = .947) or cold ischemia (P = .532). Donor age and cold ischemia time were not predictive of delayed graft function (OR = 0.86,1.20; P = .8, .6) or DCGF (HR = 1.38,0.35, P = .5, .1). These findings may alleviate concerns surrounding the utilization of kidneys from older donors or those originating from distant transplant centers.

Indexed as

AdolescentAdultAgedCold IschemiaDelayed Graft FunctionFemaleFollow-Up StudiesGraft RejectionGraft SurvivalHumansKidney Failure, ChronicKidney TransplantationLiving DonorsMaleMiddle AgedOrgan Preservationclinical research/practicedonors and donationdonors and donation: livingdonors and donation: paired exchangekidney transplantation/nephrologyorgan procurement and allocation

Identifiers

PMID31278819
PMCPMC7010231

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.