ArticleEndocrine2019
Primary adrenal schwannoma: a series of 31 cases emphasizing their clinicopathologic features and favorable prognosis.
Article in Endocrine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Adrenal schwannomas and adrenal ganglioneuromas: our experience and CT characteristic-focused systematic review.Endocrine · 2026Pooled it
- Incidental detection of adrenal schwannoma: a case report.Journal of medical case reports · 2026Article
- Adrenal Schwannoma Presenting as an Incidentaloma in a Patient with Uterine Fibroids and Cholelithiasis: a Rare Case Report.Indian journal of surgical oncology · 2024Article
- Rare adrenal schwannoma treated with robotic-assisted adrenalectomy: A case report.Urology case reports · 2024Article
- Clinical and radiological features of intracranial ancient schwannomas: a single-institution, retrospective analysis.Brain tumor pathology · 2024Article
- Co-Existing Ectopic Cortisol-Producing Adenoma and Retroperitoneal Schwannoma, a Rare Case Report.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Adrenal schwannoma can be FDG-Avid on PET/CT: case report and review of historic institutional pathology.Diagnostic pathology · 2023Article
- An unusual finding after adrenal surgery: a case series of adrenal schwannomas.Frontiers in surgery · 2023Article
- A Rare Case of an Adrenal Schwannoma.Cureus · 2023Article
- Review
- Intracranial ancient schwannoma originating from vestibular nerve: A case report and review of the literature.Surgical neurology international · 2022Article
- Adrenal Schwannoma in an Elderly Man: A Case Report and Literature Review.Internal medicine (Tokyo, Japan) · 2022Review
- Clinical presentation, management, and research progress of adrenal schwannoma.Frontiers in surgery · 2022Article
- Virtual or real: lifelike cinematic rendering of adrenal tumors.Quantitative imaging in medicine and surgery · 2021Review
- Para-adrenal schwannoma mimicking a giant adrenal lesion.BMJ case reports · 2021Article
- A big encapsulated adrenal mass with well-circumscribed margin.Urology case reports · 2021Article
- Terminal Deoxynucleotidyl Transferase Commonly Expresses in Germ Cell Tumors: Evaluation on a Large Series from Multiple Centers.International journal of general medicine · 2021Article
- Benign adrenal and suprarenal retroperitoneal schwannomas can mimic aggressive adrenal malignancies: case report and review of the literature.Intractable & rare diseases research · 2020Article
- Two giant retroperitoneal schwannomas mimicking adrenal malignancy - a case report.Innovative surgical sciences · 2020Article
- Schwannoma Misdiagnosed as Adrenal Adenoma: A Case Report and Review of the Literature.Case reports in endocrinology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePrimary adrenal schwannoma (PAS) is a very rare benign tumor, and most of them have been described in case reports. This study aimed to analyze their distinct clinicopathologic features and follow-up data through the largest series yet.
methodsClinicopathologic features of 31 primary adrenal schwannomas were retrospectively studied. Imaging and histologic features were re-evaluated and summarized. Immunohistochemical markers were measured, including S100, SOX10, AE1/AE3, EMA, SMA, Desmin, HMB45, GLUT1, and Ki67. Follow-up of all cases was performed.
resultsAll the tumors were clinically misdiagnosed as nonfunctioning adrenal adenoma (NAA; 23/31), aldosterone-producing adenoma/aldosteronoma (APA; 3/31), cortisol-producing adenoma (CPA; 3/31), or pheochromocytoma (PCC; 2/31). Some 87% (27/31) presented with adrenal incidentaloma, and 13% (4/31) had a clinical symptom or unregulated hormone levels. They comprised conventional (19/31), cellular (7/31), plexiform (2/31), ancient (1/31), epithelioid (1/31) and microcystic/reticular variants (1/31) and had various histologic features. Immunohistochemically, all tumors (31/31) were positive for S100 and Sox10, with a low Ki-67 proliferative index. In the long-term follow-up (mean, 53 mo.; median, 56 mo.), none had evidence of recurrence and metastasis. Univariate analysis showed that OS and DFS were not associated with age; sex; tumor side, size, or number; adrenal-related symptoms; gross feature (solid vs. cystic); or any histologic feature (P > 0.9999).
conclusionPAS is an extremely rare tumor and mostly appears as an incidentaloma. Clinically, it tends to be misdiagnosed as other common adrenal tumors. This tumor has a benign biologic behavior and prognosis, without correlations with clinical or histologic parameters.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.