ArticleDer Orthopade2019
[Histopathological Charcot score on intraoperative tissue samples from the foot : A prospective investigation].
Article in Der Orthopade, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- [Histopathological diagnostics of infections in rheumatology].Zeitschrift fur Rheumatologie · 2025Review
- Histopathological assessment of a two-stage reconstructive procedure of the infected Charcot foot.Archives of orthopaedic and trauma surgery · 2023Article
- [Does inflammatory activity of Charcot foot affect successful corrective arthrodesis?]Orthopadie (Heidelberg, Germany) · 2022Article
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4 authors.
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Abstract
backgroundCharcot neuropathy is a severe complication in patients with neuropathy. Without treatment, CN can lead to a destruction and collapse of the foot, with subsequent ulceration and infection. Finding an early diagnosis is essential and is based on clinical and radiological parameters (X-ray and MRI) because there is still no specific and reliable test. GOAL: Defining and validation of a Charcot score with defined histopathologic criteria.
methodTissue samples from 37 surgeries (Charcot-group n = 20, control-group n = 17) from tarsal bones were taken prospectively. A semiquantitative histopathological score based on four defined criteria of fibrous-osteo-cartilage tissues (maximum 21 points) was defined, the scoring modalities were orientated towards the evaluated HOES score (histopathological osteomyelitis evaluation score) for osteomyelitis. A comparison of the Charcot-group with diabetes mellitus and verified CN as well as neuropathy with the control group with signs of CN or neuropathy was performed.
resultsSignificant differences could be shown between the Charcot group and the control group in the score (10.5 vs 3.5 pts, p-value <0.001). There was a high significant correlation between the established tools for diagnostics of CN and the score (p-value <0,001).
conclusionThe histopathological Charcot score can detect a CN with high significance and correlates with high significance to established diagnostic tools for CN. It could represent a simple and cost-effective additive tool to verify CN in uncertain cases.
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