Evidence map›Paper›PMID 31278521›Full record

Trial reportClinical research in cardiology : official journal of the German Cardiac Society2020

Culprit vessel-related myocardial mechanics and prognostic implications following acute myocardial infarction.

Sören J Backhaus, Johannes T Kowallick, Thomas Stiermaier, Torben Lange, Alexander Koschalka, Jenny-Lou Navarra, Joachim Lotz, Shelby Kutty, Boris Bigalke, Matthias Gutberlet and 5 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00712101 phase3completednot on this map

Prospective Randomized Controlled Clinical Study to Compare Abciximab-bolus i.v. Versus i.c. in Primary PCI in Patients With Acute ST-elevation Myocardial Infarction

TypeinterventionalSponsorUniversity of LeipzigRan2008 to 2011Enrolled1,912ConditionsST-elevation Myocardial InfarctionArmsabciximab intracoronary, abciximab intravenously
NCT01612312 phase4completednot on this map

Thrombus Aspiration in ThrOmbus Containing culpRiT Lesions in Non-ST-Elevation Myocardial Infarction (TATORT-NSTEMI)

TypeinterventionalSponsorUniversity of LeipzigRan2011 to 2016Enrolled400ConditionsNon-ST-elevation Myocardial InfarctionArmsThrombectomy, Standard percutaneous coronary intervention
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Multivessel versus culprit-only PCI in STEMI patients with multivessel disease: meta-analysis of randomized controlled trials.Clinical research in cardiology : official journal of the German Cardiac Society · 2020
    Pooled it
  3. Cardiovascular magnetic resonance-derived left atrioventricular coupling index and major adverse cardiac events in patients following acute myocardial infarction.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Trial
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  17. Observational
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  19. Myocardial salvage is increased after sympathetic renal denervation in a pig model of acute infarction.Clinical research in cardiology : official journal of the German Cardiac Society · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Sören J BackhausDepartment of Cardiology and Pneumology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.
Johannes T KowallickGerman Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Göttingen, Germany.
Thomas StiermaierMedical Clinic II (Cardiology/Angiology/Intensive Care Medicine), University Heart Center Lübeck, University Hospital Schleswig-Holstein, Lübeck, Germany.
Torben LangeDepartment of Cardiology and Pneumology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.
Alexander KoschalkaDepartment of Cardiology and Pneumology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.
Jenny-Lou NavarraDepartment of Cardiology and Pneumology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.
Joachim LotzGerman Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Göttingen, Germany.
Shelby KuttyChildren's Hospital and Medical Center, University of Nebraska College of Medicine, Omaha, NE, 68114, USA.
Boris BigalkeDepartment of Cardiology, Charité Campus Benjamin Franklin, University Medical Center Berlin, Berlin, Germany.
Matthias GutberletInstitute of Diagnostic and Interventional Radiology, Heart Center Leipzig at University of Leipzig, Leipzig, Germany.
Hans-Josef FeistritzerDepartment of Internal Medicine/Cardiology, Heart Center Leipzig at University of Leipzig, Leipzig, Germany.
Gerd HasenfußDepartment of Cardiology and Pneumology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.
Holger ThieleDepartment of Internal Medicine/Cardiology, Heart Center Leipzig at University of Leipzig, Leipzig, Germany.
Andreas SchusterDepartment of Cardiology and Pneumology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany. andreas_schuster@gmx.net.
Ingo EitelMedical Clinic II (Cardiology/Angiology/Intensive Care Medicine), University Heart Center Lübeck, University Hospital Schleswig-Holstein, Lübeck, Germany.
Leipzig Heart Institute · DEUniversitätsmedizin Göttingen · DEUniversity of Göttingen · DEGerman Centre for Cardiovascular Research · DECharité - Universitätsmedizin Berlin · DEChildren's Hospital & Medical Center · USUniversity Hospital Schleswig-Holstein · DEUniversity of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrognosis in acute myocardial infarction (AMI) depends on the amount of infarct-related artery (IRA)-subtended myocardium and associated damage but has not been described in great detail. Consequently, we sought to describe IRA-associated pathophysiological consequences using cardiac magnetic resonance (CMR).

methods1235 AMI patients (n = 795 ST-elevation (STEMI) and 440 non-STEMI) underwent CMR following percutaneous coronary intervention. Blinded core-laboratory data were compared according to left anterior descending (LAD), left circumflex (LCx) and right coronary artery (RCA) regarding major adverse clinical events (MACE) within 12 months. Left ventricular (LV) global longitudinal/circumferential/radial (GLS/GCS/GRS) as well as left atrial (LA) total (ε

resultsLAD and LCx were associated with higher mortality compared to RCA lesions (4.6% and 4.4% vs 1.6%). LAD lesions showed largest IS (16.8%), largest ventricular [LV ejection fraction (EF) 47.4%, GLS - 13.2%, GCS - 20.8%] and atrial (ε

conclusionsCMR allows IRA-specific phenotyping and characterisation of morphologic and functional changes. These alterations carry infarct-specific prognostic implications, and may represent novel diagnostic and therapeutic targets following AMI.

trial registrationClinicalTrials.gov: NCT00712101 and NCT01612312.

Indexed as

Magnetic Resonance ImagingPercutaneous Coronary InterventionAgedAtrial Function, LeftFemaleHumansMaleMiddle AgedNon-ST Elevated Myocardial InfarctionPrognosisST Elevation Myocardial InfarctionVentricular Function, LeftCardiac functionCardiovascular magnetic resonanceFeature trackingInfarct-related arteryPrognosis

Identifiers

PMID31278521
OpenAlexW2955276673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.