SynthesisDiabetologia2019
Neurocognitive and behavioural outcomes in offspring exposed to maternal pre-existing diabetes: a systematic review and meta-analysis.
Synthesis in Diabetologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Preexisting diabetes and gestational diabetes as risk factors for autism spectrum disorder: an umbrella review.Frontiers in public health · 2026Pooled it
- The association between maternal diabetes and the risk of attention deficit hyperactivity disorder in offspring: an updated systematic review and meta-analysis.European child & adolescent psychiatry · 2025Pooled it
- Pooled it
- How Do the Different Types of Maternal Diabetes during Pregnancy Influence Offspring Outcomes?Nutrients · 2022Pooled it
- Neurodevelopmental outcomes of children born to diabetic mothers in the Qatari population: a retrospective study.BMJ paediatrics open · 2026Article
- Effect of gestational diabetes on neurodevelopment outcome of the offsprings- Ma'an shan birth cohort study.BMC pediatrics · 2025Article
- Maternal Fasting Plasma Glucose Level in Early Gestation and Developmental Delay in 2-year-old Children.The Journal of clinical endocrinology and metabolism · 2025Article
- Diabetes in Pregnancy and School-Age Developmental Outcomes for Offspring: A Statewide Retrospective Cohort Study.Diabetes care · 2025Article
- Prenatal valproic acid on the basis of gestational diabetes also induces autistic behavior and disrupts myelination and oligodendroglial maturation slightly in offspring.Translational psychiatry · 2025Article
- Association between maternal glycohemoglobin in pregnancy and adult offspring cognition: results from the Transgenerational Effects of Adult Morbidity (TEAM) Study.Journal of developmental origins of health and disease · 2025Article
- Review
- Clinical Characteristics of Offspring Born to Parents with Type 2 Diabetes Diagnosed in Youth: Observations from TODAY.Children (Basel, Switzerland) · 2024Article
- Medication Usage Record-Based Predictive Modeling of Neurodevelopmental Abnormality in Infants under One Year: A Prospective Birth Cohort Study.Healthcare (Basel, Switzerland) · 2024Article
- Maternal type 1 diabetes, preterm birth, and risk of intellectual disability in the offspring: A nation-wide study in Sweden.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Periconceptional Serum Creatinine and Risk of Childhood Autism Spectrum Disorder: A Research Letter.Canadian journal of kidney health and disease · 2024Article
- Risk cycling in diabetes and autism spectrum disorder: a bidirectional Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Executive function and behaviour problems in school-age children born at risk of neonatal hypoglycaemia.Developmental medicine and child neurology · 2023Article
- Review
- Maternal metabolic syndrome in pregnancy and child development at age 5: exploring mediating mechanisms using cord blood markers.BMC medicine · 2023Article
- Robust determinants of neurocognitive development in children: evidence from the Pune Maternal Nutrition Study.Journal of developmental origins of health and disease · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
aims/hypothesisWe performed a systematic review and meta-analysis to determine whether exposure to maternal pre-existing diabetes in pregnancy is associated with neurocognitive or behavioural outcomes in offspring.
methodsWe searched MEDLINE, EMBASE, PsychINFO, the Cochrane Database of Systematic Reviews and Scopus for studies that examined any neurocognitive or behavioural outcomes in offspring of mothers with pre-existing diabetes in pregnancy in accordance with a published protocol (PROSPERO CRD42018109038). Title and abstract review, full-text review and data extraction were performed independently and in duplicate. Risk of bias was assessed using the Newcastle-Ottawa scale. Meta-analyses of summary measures were performed using random-effects models.
resultsNineteen articles including at least 18,681 exposed and 2,856,688 control participants were identified for inclusion. Exposure to maternal pre-existing diabetes in pregnancy was associated with a lower pooled intelligence quotient in the offspring (pooled weighted mean difference -3.07 [95% CI -4.59, -1.55]; I CONCLUSIONS/
interpretationThere is evidence to suggest that in utero exposure to maternal pre-existing diabetes is associated with some adverse neurocognitive and behavioural outcomes. It remains unclear what the role of perinatal factors is and the degree to which other environmental factors contribute to these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.