ArticleScientific reports2019
Antibiotic drug-resistance as a complex system driven by socio-economic growth and antibiotic misuse.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 92 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
92 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Current State of Knowledge Regarding WHO High Priority Pathogens-Resistance Mechanisms and Proposed Solutions through Candidates Such as Essential Oils: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- High prevalence of antibiotic resistance in commensal Escherichia coli from healthy human sources in community settings.Scientific reports · 2021Pooled it
- Molecular determinants of antimicrobial resistance inMicrobiology spectrum · 2026Article
- Mapping the landscape of mathematical models for antimicrobial resistance: a scoping review.BMC public health · 2026Article
- Nanotechnology revolutionizing antimicrobial therapy for superbug infections.Discover nano · 2026Review
- Nanoparticle-Based Strategies to Combat Multidrug-Resistant Bacteria: Mechanisms, Applications, and Future Perspectives.MicrobiologyOpen · 2026Review
- Antimicrobial Armageddon: The Professional Guide to Conquering Antibiotic Resistance.Probiotics and antimicrobial proteins · 2026Article
- A green approach for synthesizing zinc oxide nanoparticles utilizing aqueous extract of lemon peel: antibacterial evaluation and in silico analysis.Frontiers in chemistry · 2026Article
- Significant gaps in practice present despite higher levels of public awareness in antibiotic use and antimicrobial resistance in the western province of Sri Lanka.Access microbiology · 2026Article
- Antivirulence Activity and Therapeutic Potential of JumboJournal of microbiology and biotechnology · 2025Article
- Evaluation of systemic inflammatory response following transcatheter aortic valve replacement: a pathway to rational antibiotic use.Infection · 2025Article
- Evaluation of current practice of antimicrobial use and clinical outcome in the management of pneumonia among pediatric patients admitted to Jimma Medical Center, Southwest Ethiopia: a prospective observational study.Annals of medicine and surgery (2012) · 2025Article
- Genomic and Computational Analysis Unveils Bacteriocin Based Therapeutics against Clinical Mastitis Pathogens in Dairy Cows.Probiotics and antimicrobial proteins · 2025Article
- Panel data analysis of spatial effects carbapenem-resistant organisms in mainland China.Scientific reports · 2025Article
- Microwave Synthesis of Fluorescent Carbon Quantum dots from Araucaria Heterophylla Gum: Application in Drug Detection.Journal of fluorescence · 2025Article
- A Cross-Sectional Study Assessing Antibiotic Resistance Awareness Among University Students in Samborondón, Greater Guayaquil, Ecuador.Antibiotics (Basel, Switzerland) · 2025Article
- Awareness program for controlling the misuse of antibiotics and related resistance among mothers of children under 5 years.Journal of health, population, and nutrition · 2025Article
- Antibiotic susceptibility of pathogens isolated in respiratory tract samples of recently hospitalized patients.Microbiology spectrum · 2025Article
- Unveiling the drivers of vancomycin-resistant enterococcus in China: A comprehensive ecological study.Infectious medicine · 2025Article
- Design of acidic activation-responsive charge-switchable carbon dots and validation of their antimicrobial activity.RSC advances · 2025Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overwhelming antibiotic use poses a serious challenge today to the public-health policymakers worldwide. Many empirical studies pointed out this ever-increasing antibiotic consumption as primary driver of the community-acquired antibiotic drug-resistance, especially in the middle- and lower-income countries. The association is well documented across spatio-temporal gradients in many parts of the world, but there is rarely any study that emphasizes the mechanism of the association, which is important for combating drug-resistance. Formulating a mathematical model of emergence and transmission of drug-resistance, we in this paper, present how amalgamating three components: socio-economic growth, population ecology of infectious disease, and antibiotic misuse can instinctively incite proliferation of resistance in the society. We show that combined impact of economy, infections, and self-medication yield synergistic interactions through feedbacks on each other, presenting the emergence of drug-resistance as a self-reinforcing cycle in the population. Analysis of our model not only determines the threshold of antibiotic use beyond which the emergence of resistance may occur, but also characterizes how fast it develops depending on economic growth, and lack of education and awareness of the population. Our model illustrates that proper and timely government aid in population health can break the self-reinforcing process and reduce the burden of drug-resistance in the community.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.