Evidence map›Paper›PMID 31278313›Full record

ArticleScientific reports2019

Adenosine A

Chiara De Nuccio, Antonietta Bernardo, Antonella Ferrante, Rita Pepponi, Alberto Martire, Mario Falchi, Sergio Visentin, Patrizia Popoli, Luisa Minghetti

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. ENT1 inhibition links oligodendrocyte lipid metabolism to connectivity in tauopathy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. AMetabolites · 2026
    Article
  3. Review
  4. Article
  5. Adenosine AFrontiers in pharmacology · 2024
    Article
  6. Adenosine ACurrent issues in molecular biology · 2023
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Understanding and Treating Niemann-Pick Type C Disease: Models Matter.International journal of molecular sciences · 2020
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Chiara De NuccioResearch Coordination and Support Service, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy. chiara.denuccio@iss.it.
Antonietta BernardoNational Center for Research and Preclinical and Clinical Evaluation of Drugs, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.ORCID http://orcid.org/0000-0002-6590-7530
Antonella FerranteNational Center for Research and Preclinical and Clinical Evaluation of Drugs, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
Rita PepponiNational Center for Research and Preclinical and Clinical Evaluation of Drugs, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
Alberto MartireNational Center for Research and Preclinical and Clinical Evaluation of Drugs, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
Mario FalchiNational Research Center on HIV/AIDS, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
Sergio VisentinNational Center for Research and Preclinical and Clinical Evaluation of Drugs, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
Patrizia PopoliNational Center for Research and Preclinical and Clinical Evaluation of Drugs, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
Luisa MinghettiResearch Coordination and Support Service, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.ORCID http://orcid.org/0000-0002-7065-4689
Istituto Superiore di Sanità · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Niemann Pick type C (NPC) disease is a rare neurovisceral disorder. Mutations in npc1 gene induce an intracellular accumulation of unesterified cholesterol in the endosomal/lysosomal system causing cell death. We recently showed that stimulation of adenosine A

Indexed as

AnimalsAutophagyCell DifferentiationCholesterolCyclic AMPCyclic AMP-Dependent Protein KinasesFibroblastsHumansMitochondriaNiemann-Pick Disease, Type COligodendrogliaReceptor, Adenosine A2ACholesterolCyclic AMPCyclic AMP-Dependent Protein KinasesReceptor, Adenosine A2A

Identifiers

PMID31278313
PMCPMC6611770
OpenAlexW2954630947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.