ArticleScientific reports2019
Engineering multi-layered tissue constructs using acoustic levitation.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Spatial patterning strategies for liver tissue engineering: Biofabrication technologies and applications.Advanced drug delivery reviews · 2026Review
- A Tissue Engineering Acoustophoretic (TEA) Set-up for the Enhanced Osteogenic Differentiation of Murine Mesenchymal Stromal Cells (mMSCs).International journal of molecular sciences · 2022Article
- The Structure and Function of Next-Generation Gingival Graft Substitutes-A Perspective on Multilayer Electrospun Constructs with Consideration of Vascularization.International journal of molecular sciences · 2022Review
- Concentration of Microparticles Using Flexural Acoustic Wave in Sessile Droplets.Sensors (Basel, Switzerland) · 2022Article
- Self-organization and culture of Mesenchymal Stem Cell spheroids in acoustic levitation.Scientific reports · 2021Article
- Ultrasound-Based Scaffold-Free Core-Shell Multicellular Tumor Spheroid Formation.Micromachines · 2021Article
- The waves that make the pattern: a review on acoustic manipulation in biomedical research.Materials today. Bio · 2021Review
- The utility of biomedical scaffolds laden with spheroids in various tissue engineering applications.Theranostics · 2021Review
- Acoustofluidic multi-well plates for enrichment of micro/nano particles and cells.Lab on a chip · 2020Article
- Coalescence Dynamics of Acoustically Levitated Droplets.Micromachines · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Engineering tissue structures that mimic those found in vivo remains a challenge for modern biology. We demonstrate a new technique for engineering composite structures of cells comprising layers of heterogeneous cell types. An acoustofluidic bioreactor is used to assemble epithelial cells into a sheet-like structure. On transferring these cell sheets to a confluent layer of fibroblasts, the epithelial cells cover the fibroblast surface by collective migration maintaining distinct epithelial and fibroblast cell layers. The collective behaviour of the epithelium is dependent on the formation of cell-cell junctions during levitation and contrasts with the behaviour of mono-dispersed epithelial cells where cell-matrix interactions dominate and hinder formation of discrete cell layers. The multilayered tissue model is shown to form a polarised epithelial barrier and respond to apical challenge. The method is useful for engineering a wide range of layered tissue types and mechanistic studies on collective cell migration.
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Registered trials
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