ArticleScientific reports2019
The UKB envirome of depression: from interactions to synergistic effects.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Illuminating the complex interplay of risk factors for depression symptoms within a large-scale US longitudinal cohort.Social psychiatry and psychiatric epidemiology · 2026Article
- Synergistic Impact of Sleep Disturbance and Social Isolation in Adult but Not Adolescent Female Mice.Journal of sleep research · 2026Article
- Interaction of early life stress and NAD + /SIRT1 pathway genetic risk promotes depression.Translational psychiatry · 2025Article
- Consumption of High-Energy Food and Sugar Shows a Strong Positive Association with Low Mood in Control Subjects and Depressed Patients.Nutrients · 2025Article
- Genome-wide by trait interaction analyses with neuroticism reveal chronic pain-associated depression as a distinct genetic subtype.Translational psychiatry · 2025Article
- Decoding depression by exploring the exposome-genome edge amidst COVID-19 lockdown.Scientific reports · 2024Article
- Olfactory genes affect major depression in highly educated, emotionally stable, lean women: a bridge between animal models and precision medicine.Translational psychiatry · 2024Article
- Predicting future onset of depression among middle-aged adults with no psychiatric history.BJPsych open · 2023Article
- Genetic risk of depression is different in subgroups of dietary ratio of tryptophan to large neutral amino acids.Scientific reports · 2023Article
- Inflammation and Blood-Brain Barrier in Depression: Interaction of CLDN5 and IL6 Gene Variants in Stress-Induced Depression.The international journal of neuropsychopharmacology · 2023Article
- Restoring the missing person to personalized medicine and precision psychiatry.Frontiers in neuroscience · 2023Article
- Exploring polygenic-environment and residual-environment interactions for depressive symptoms within the UK Biobank.Genetic epidemiology · 2022Article
- Article
- Every Night and Every Morn: Effect of Variation inFrontiers in psychiatry · 2021Article
- A replication study separates polymorphisms behind migraine with and without depression.PloS one · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder is a result of the complex interplay between a large number of environmental and genetic factors but the comprehensive analysis of contributing environmental factors is still an open challenge. The primary aim of this work was to create a Bayesian dependency map of environmental factors of depression, including life stress, social and lifestyle factors, using the UK Biobank data to determine direct dependencies and to characterize mediating or interacting effects of other mental health, metabolic or pain conditions. As a complementary approach, we also investigated the non-linear, synergistic multi-factorial risk of the UKB envirome on depression using deep neural network architectures. Our results showed that a surprisingly small number of core factors mediate the effects of the envirome on lifetime depression: neuroticism, current depressive symptoms, parental depression, body fat, while life stress and household income have weak direct effects. Current depressive symptom showed strong or moderate direct relationships with life stress, pain conditions, falls, age, insomnia, weight change, satisfaction, confiding in someone, exercise, sports and Townsend index. In conclusion, the majority of envirome exerts their effects in a dynamic network via transitive, interactive and synergistic relationships explaining why environmental effects may be obscured in studies which consider them individually.
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