Evidence map›Paper›PMID 31278284›Full record

ArticleScientific reports2019

Association of TLR4 and TLR9 polymorphisms and haplotypes with cervical cancer susceptibility.

Nilesh O Pandey, Alex V Chauhan, Nitin S Raithatha, Purvi K Patel, Ronak Khandelwal, Ajesh N Desai, Yesha Choxi, Rutul S Kapadia, Neeraj D Jain

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In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Nilesh O PandeyP D Patel Institute of Applied Sciences, Charotar University of Science and Technology (CHARUSAT), Changa, Anand, India.
Alex V ChauhanP D Patel Institute of Applied Sciences, Charotar University of Science and Technology (CHARUSAT), Changa, Anand, India.
Nitin S RaithathaDepartment of Obstetrics and Gynaecology, Pramukh Swami Medical College, Shree Krishna Hospital, Karamsad, Anand, India.
Purvi K PatelDepartment of Obstetrics and Gynaecology, Sir Sayajirao General Hospital and Medical College, Vadodara, India.
Ronak KhandelwalDepartment of Obstetrics and Gynaecology, Sir Sayajirao General Hospital and Medical College, Vadodara, India.
Ajesh N DesaiDepartment of Obstetrics & Gynaecology, GMERS Medical College and Hospital, Ahmedabad, India.
Yesha ChoxiDepartment of Obstetrics & Gynaecology, GMERS Medical College and Hospital, Ahmedabad, India.
Rutul S KapadiaDepartment of Obstetrics & Gynaecology, GMERS Medical College and Hospital, Ahmedabad, India.
Neeraj D JainP D Patel Institute of Applied Sciences, Charotar University of Science and Technology (CHARUSAT), Changa, Anand, India. neerajjain.as@charusat.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single nucleotide polymorphisms (SNPs) in TLR genes may serve as a crucial marker for early susceptibility of various cancers including cervical cancer. The present study was therefore designed to ascertain the role of TLR4 and TLR9 SNPs and haplotypes to hrHPV infection and cervical cancer susceptibility. The study included 110 cervical cancer biopsies and 141 cervical smears from age-matched healthy controls of Gujarati ethnicity of Western India. hrHPV 16 and 18 were detected using Real-time PCR. Eight SNPs, four each in TLR4 and TLR9 were analyzed using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism and Allele-Specific PCR. HPV 16 and 18 were detected in 68% cervical cancer cases. TLR4 rs4986790, rs1927911 and TLR9 rs187084 showed association with HPV 16/18 infection. CC and CT genotypes of TLR4 rs11536889 and rs1927911 respectively, and TC, CC genotypes of TLR9 rs187084, as well as minor alleles of TLR4 rs4986790 and TLR9 rs187084, were associated with the increased risk of cervical cancer. Stage-wise analysis revealed TLR9 rs187084 and rs352140 to be associated with early-stage cancer. TLR4 haplotype GTAC and TLR9 haplotype GATC were associated with the increased risk of cervical cancer while TLR4 haplotype GCAG was associated with the decreased risk. TLR4 haplotype GCAG and TLR9 haplotype GATC showed association with increased susceptibility to hrHPV infection. In conclusion, the present study revealed association of TLR4 and TLR9 polymorphisms and haplotypes with hrHPV infection and cervical cancer risk. Further evaluation of a larger sample size covering diverse ethnic populations globally is warranted.

Indexed as

AdultCase-Control StudiesFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHaplotypesHuman papillomavirus 16Human papillomavirus 18HumansMiddle AgedPapillomavirus InfectionsPolymorphism, Restriction Fragment LengthPolymorphism, Single NucleotideToll-Like Receptor 4Toll-Like Receptor 9TLR4 protein, humanTLR9 protein, humanToll-Like Receptor 4Toll-Like Receptor 9

Identifiers

PMID31278284
PMCPMC6611874

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.