Evidence map›Paper›PMID 31278002›Full record

ArticleBiophysical journal2019

A Structural Model of the Inactivation Gate of Voltage-Activated Potassium Channels.

Ariela Vergara-Jaque, Francisco Palma-Cerda, Adam S Lowet, Angel de la Cruz Landrau, Horacio Poblete, Alexander Sukharev, Jeffrey Comer, Miguel Holmgren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ariela Vergara-JaqueMultidisciplinary Scientific Nucleus, Center for Bioinformatics and Molecular Simulation; Millennium Nucleus of Ion Channels-associated Diseases (MiNICAD), Universidad de Talca, Talca, Chile; Institute of Computational Comparative Medicine, Nanotechnology Innovation Center of Kansas State, Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas.
Francisco Palma-CerdaMolecular Neurophysiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Adam S LowetMolecular Neurophysiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Angel de la Cruz LandrauMolecular Neurophysiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Horacio PobleteMultidisciplinary Scientific Nucleus, Center for Bioinformatics and Molecular Simulation; Millennium Nucleus of Ion Channels-associated Diseases (MiNICAD), Universidad de Talca, Talca, Chile; Institute of Computational Comparative Medicine, Nanotechnology Innovation Center of Kansas State, Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas.
Alexander SukharevMolecular Neurophysiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Jeffrey ComerInstitute of Computational Comparative Medicine, Nanotechnology Innovation Center of Kansas State, Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas. Electronic address: jeffcomer@ksu.edu.
Miguel HolmgrenMolecular Neurophysiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland. Electronic address: holmgren@ninds.nih.gov.

Funding

Structure and Function of Membrane ProteinsZIANS002993 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI HOLMGREN, MIGUEL · 2009 to 2025
$24.0M
Structure and Function of Membrane ProteinsZ01NS002993 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI HOLMGREN, MIGUEL · 2002 to 2008
$1.1M
Intramural NIH HHS Z01 NS002993
6 · The paper itself

Abstract

After opening, the Shaker voltage-gated potassium (K

Indexed as

Ion Channel GatingModels, MolecularAmino AcidsHEK293 CellsHumansHydrophobic and Hydrophilic InteractionsMolecular Dynamics SimulationPotassium Channels, Voltage-GatedProtein FoldingProtein Structure, SecondaryReproducibility of ResultsThermodynamicsAmino AcidsPotassium Channels, Voltage-Gated

Identifiers

PMID31278002
PMCPMC6702135

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.