Evidence map›Paper›PMID 31277894›Full record

ReviewNeurobiology of aging2019

Innovative approaches in cognitive aging.

Steven N Austad, Marcelo A Wood, Saul A Villeda, Joel L Voss, Amar Sahay, Marilyn Albert

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The adaptive aging brain.Current opinion in neurobiology · 2022
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Steven N AustadDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Marcelo A WoodDepartment of Neurobiology and Behavior, School of Biological Sciences, University of California, Irvine, CA, USA.
Saul A VilledaDepartment of Anatomy, School of Medicine, University of California, San Francisco, CA, USA.
Joel L VossDepartment of Medical Social Sciences, Ken and Ruth Davee Department of Neurology, Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Amar SahayHarvard Stem Cell Institute, BROAD Institute of MIT and Harvard, Center for Regenerative Medicine, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Marilyn AlbertDepartment of Neurology, The Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: malbert9@jhmi.edu.

Funding

Project 2 MeasurementU19AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2014 to 2026
$51.5M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6M
Sex hormones and arthritis in a long lived animal modelP30AG050886 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Jianhua Zhang · 2015 to 2026
$11.3M
ENERGETICS DISPARITIES & LIFESPAN: A UNIFIED HYPOTHESISR01AG043972 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALLISON, DAVID B · 2012 to 2016
$8.3M
Epigenetic suppression of histone methylation reverses age and AD-related cognitive declineRF1AG057558 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI WOOD, MARCELO ANDRES · 2018 to 2018
$3.8M
Exercise-induced epigenetic mechanisms underlying neuronal plasticity and cognitionR01AG051807 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI COTMAN, CARL WAYNE, WOOD, MARCELO ANDRES · 2016 to 2020
$3.1M
Noninvasive Stimulation to Improve Hippocampal-Dependent Memory in Older AdultsR01AG049002 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HAUNER, KATHERINA · 2015 to 2020
$2.8M
Molecular control of excitation-inhibition balance to encode ambiguous threatsR01MH104175 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SAHAY, AMAR · 2014 to 2018
$2.7M
Re-engineering excitation-inhibition connectivity to rejuvenate memory circuits in agingRF1AG048908 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI SAHAY, AMAR · 2016 to 2016
$2.0M
Investigating the pro-aging role of B2M and MHC molecules on regenerative and cognitive function in the brainR01AG055797 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VILLEDA, SAUL A · 2017 to 2021
$1.6M
Role of HDAC3 in repressing memory formation in the aging brainR21AG050787 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI WOOD, MARCELO ANDRES · 2016 to 2017
$425k
NIA NIH HHS P30 AG050886NIA NIH HHS P50 AG005146NIA NIH HHS R01 AG043972NIA NIH HHS R01 AG049002NIA NIH HHS R01 AG051807NIA NIH HHS R01 AG055797NIA NIH HHS R21 AG050787NIA NIH HHS RF1 AG048908NIA NIH HHS RF1 AG057558NIA NIH HHS U19 AG033655NIMH NIH HHS R01 MH104175
6 · The paper itself

Abstract

Novel approaches to address cognitive aging and to delay or prevent cognitive decline in older individuals will require a better understanding of the biological and environmental factors that contribute to it. Studies in animal models-in particular, animals whose cognitive trajectory across their life span closely tracks that of humans-can provide important insights into the factors that contribute to the accumulation of reserve and ways in which it is preserved or depleted. A better understanding of the molecular processes that underlie these elements would enhance and guide not only research but also treatment approaches to these issues. These treatment approaches may include noninvasive brain stimulation and drug treatments to promote youthfulness or combat the aging process. It is important to realize, however, that these processes occur in the context of the human experience, and studies of them must consider the complexity and individuality of each person's life.

Indexed as

AgingAnimalsBrainCognitionCognitive AgingCognitive ReserveHumansIndividualityEpigeneticsInterventionNovel approachesRegenerationReserveResilience

Identifiers

PMID31277894
PMCPMC7039185

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.