Evidence map›Paper›PMID 31277775›Full record

ArticleEuropean urology oncology2019

Delaying Radical Cystectomy After Neoadjuvant Chemotherapy for Muscle-invasive Bladder Cancer is Associated with Adverse Survival Outcomes.

Luca Boeri, Matteo Soligo, Igor Frank, Stephen A Boorjian, R Houston Thompson, Matthew Tollefson, Fernando J Quevedo, John C Cheville, R Jeffrey Karnes

Abstract read
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In one paragraph

Article in European urology oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. [Recommendations CCAFU on the management of cancers of the urogenital system during an epidemic with Coronavirus COVID-19].Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie · 2020
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  19. [Perioperative systemic treatment of urothelial cancer].Urologie (Heidelberg, Germany) · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Luca BoeriDepartment of Urology, Mayo Clinic, Rochester, MN, USA; Department of Urology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Matteo SoligoDepartment of Urology, Mayo Clinic, Rochester, MN, USA.
Igor FrankDepartment of Urology, Mayo Clinic, Rochester, MN, USA.
Stephen A BoorjianDepartment of Urology, Mayo Clinic, Rochester, MN, USA.
R Houston ThompsonDepartment of Urology, Mayo Clinic, Rochester, MN, USA.
Matthew TollefsonDepartment of Urology, Mayo Clinic, Rochester, MN, USA.
Fernando J QuevedoDepartment of Medical Oncology, Mayo Clinic, Rochester, MN, USA.
John C ChevilleDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
R Jeffrey KarnesDepartment of Urology, Mayo Clinic, Rochester, MN, USA. Electronic address: karnes.r@mayo.edu.
Mayo Clinic in Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDelaying radical cystectomy (RC) after a diagnosis of muscle-invasive bladder cancer (MIBC) has been associated with adverse survival. However, data are lacking regarding the impact of RC delay in patients receiving neoadjuvant chemotherapy (NAC).

objectivesTo assess whether the time from last cycle of NAC to RC (time to cystectomy, TTC) is associated with survival among MIBC patients. DESIGN, SETTING, AND

participantsThe study cohort comprised 226 patients treated with NAC and RC between 1999 and 2015 for cT2-T4N0M0 bladder cancer. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Descriptive statistics were used to test the association between TTC and clinicopathologic variables. Overall mortality (OM) and cancer-specific mortality (CSM) were analyzed via Kaplan-Meier estimation according to TTC. We assessed factors associated with OM and CSM using multivariable Cox regression analyses. RESULTS AND LIMITATIONS: The median TTC was 7.57wk (interquartile range 5.2-10.8). Patients with a Charlson comorbidity index (CCI) ≥1 had a longer TTC than those with a score of <1 (p=0.027). The group with TTC >10wk had significantly lower OM-free (p=0.003) and CSM-free rates (p<0.001) than the group with TTC ≤10wk. TTC was independently associated with higher risk of OM (p=0.027) and CSM (p=0.004) after accounting for age, gender, pathologic extravesical disease, and nodal status.

conclusionsTTC of >10wk after NAC was associated with adverse survival among patients with MIBC. Patients with a higher CCI were more likely to have prolonged TTC. PATIENT SUMMARY: The impact of delaying radical cystectomy in patients who have received neoadjuvant chemotherapy (NAC) is unknown. In this study we assessed whether prolonged time to cystectomy (TTC) after NAC affects survival outcomes in patients with muscle-invasive bladder cancer. We found that TTC of >10wk was associated with adverse overall survival and cancer-specific survival, and attempts should be made to shorten TTC after preoperative chemotherapy.

Indexed as

CystectomyMuscle NeoplasmsNeoadjuvant TherapyUrinary Bladder NeoplasmsAdultAgedAged, 80 and overAntineoplastic AgentsChemotherapy, AdjuvantFemaleHumansKaplan-Meier EstimateMaleMiddle AgedTime-to-TreatmentAntineoplastic AgentsBladder cancerNeoadjuvant chemotherapyRadical cystectomyRisk factorsSurgery delay

Identifiers

PMID31277775
OpenAlexW2893208123

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.