ArticleArthritis research & therapy2019
Assessing synovitis in the hands in patients with rheumatoid arthritis by ultrasound: an agreement study exploring the most inflammatory active side from two Norwegian trials.
Article in Arthritis research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Baseline synovitis-tenosynovitis is associated with remission in early rheumatoid arthritis, but discordance with disease activity is a changeable state.Rheumatology (Oxford, England) · 2025Trial
- Ultrasound to Assess the Temporomandibular Joint of Children With Juvenile Idiopathic Arthritis: A Systematic Review.International journal of dentistry · 2026Review
- A cohort study of ultrasonic semi-quantitative scoring for the diagnosis of serology-negative rheumatoid arthritis.Archives of rheumatology · 2024Article
- Variation of sexual dimorphism and asymmetry in disease expression of inflammatory arthritis among laboratory mouse models with different genomic backgrounds.Laboratory animal research · 2023Article
- High-frequency ultrasound in patients with seronegative rheumatoid arthritis.Scientific reports · 2022Article
- Flare during tapering of biological DMARDs in patients with rheumatoid arthritis in routine care: characteristics and predictors.RMD open · 2022Article
- Artificial Intelligence and Deep Learning for Rheumatologists.Arthritis & rheumatology (Hoboken, N.J.) · 2022Review
- Ultrasound in the evaluation of rheumatoid arthritis.European journal of rheumatology · 2022Article
- Synovial Fibrosis Involvement in Osteoarthritis.Frontiers in medicine · 2021Review
- Validity and diagnostic performance of fluorescence optical imaging measuring synovitis in hand osteoarthritis: baseline results from the Nor-Hand cohort.Arthritis research & therapy · 2020Article
- The changing role of ultrasonography examination in patients with rheumatoid arthritis in light of recent studies.Reumatologia · 2020Review
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Authors and funding
6 authors.
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Abstract
objectiveTo assess if the right hand, the dominant hand, or the hand with more clinically swollen joints (SwJ) is per se the most inflamed and exhibits the greatest change during treatment and hence preferred for unilateral scoring of synovitis by ultrasound in rheumatoid arthritis (RA) patients.
methodsUsing data from two previously published Norwegian RA patient cohorts initiating treatment, bilateral metacarpophalangeal joint 1-5, proximal phalangeal joint 2+3, and wrists were evaluated by ultrasound. Using a 0-3 scoring system a grey-scale (GS), power Doppler (PD) and global synovitis score (GLOESS) was calculated for each hand (0-30). For precision, a difference of < ± 3 in sum score was pre-specified as indicating clinically insignificant difference in inflammatory activity for all three scores.
resultsFour hundred thirty-seven RA patients were included. Baseline ultrasound inflammation was statistically significantly higher in hands with more vs fewer SwJ ([mean difference, 95%CI] GS sum score 2.21[1.30 to 3.12], PD sum score 1.70 [0.94 to 2.47] and GLOESS 2.31[1.36 to 3.26]) and also exhibited significantly more change for all sum scores at 3 months follow-up (GS sum score 1.34 [0.60 to 2.08], PD sum score 1.17 [0.44 to 1.91], and GLOESS 1.43 [0.63 to 2.22]). No such differences were found between the dominant and the non-dominant or the right and the left hands at any time points.
conclusionThe hand with clinically more SwJ is statistically more inflammatory active according to GS, Doppler, and GLOESS sum scores, exhibits a change during treatment, and is potentially the best choice for unilateral scoring systems.
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