Evidence map›Paper›PMID 31277663›Full record

ReviewMolecular cancer2019

Exosomal circRNAs: biogenesis, effect and application in human diseases.

Yangxia Wang, Jinbo Liu, Junfen Ma, Ting Sun, Quanbo Zhou, Weiwei Wang, Guixian Wang, Pingjun Wu, Haijiang Wang, Li Jiang and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 416 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
416citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

416 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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356 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yangxia WangKey Clinical Laboratory of Henan Province, Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Jinbo LiuDepartment of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Junfen MaKey Clinical Laboratory of Henan Province, Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Ting SunKey Clinical Laboratory of Henan Province, Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Quanbo ZhouDepartment of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Weiwei WangDepartment of Pathology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, Henan, China.
Guixian WangDepartment of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Pingjun WuDepartment of Cardiac surgery, The Third People's Hospital of Henan Province, Zhengzhou, 450000, Henan, China.
Haijiang WangDepartment of Gastrointestinal Surgery, Affiliated Tumor Hospital, Xinjiang Medical University, Ürümqi, 830011, Xinjiang, China.
Li JiangDepartment of Radiotherapy, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, Henan, China.
Weitang YuanDepartment of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Zhenqiang SunDepartment of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. zqsun82@csu.edu.cn.ORCID 0000-0001-5926-2716
Liang MingKey Clinical Laboratory of Henan Province, Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. lmingzzu@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes have emerged as critical mediators of intercellular communication, both locally and systemically, by regulating a diverse range of biological processes between cells. Circular RNA (circRNA) is a novel member of endogenous noncoding RNAs with widespread distribution and diverse cellular functions. Recently, circular RNAs have been identified for their enrichment and stability in exosomes. In this review, we outline the origin, biogenesis and function of exosomal circRNAs as well as their roles in various diseases. Although their precise roles and mechanisms of gene regulation remain largely elusive, exosomal circRNAs have potential applications as disease biomarkers and novel therapeutic targets.

Indexed as

BiomarkersExosomesLiquid BiopsyMolecular Diagnostic TechniquesRNA, CircularCell-Derived MicroparticlesExtracellular VesiclesHumansNeoplasmsBiomarkersRNA, CircularBiomarkerCircRNAExosomal circRNAExosomeTumor microenvironment

Identifiers

PMID31277663
PMCPMC6610963

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.