Evidence map›Paper›PMID 31277659›Full record

Trial reportRespiratory research2019

Bleeding risk of transbronchial cryobiopsy compared to transbronchial forceps biopsy in interstitial lung disease - a prospective, randomized, multicentre cross-over trial.

Juergen Hetzel, Ralf Eberhardt, Christoph Petermann, Wolfgang Gesierich, Kaid Darwiche, Lars Hagmeyer, Rainer Muche, Michael Kreuter, Richard Lewis, Ahmed Ehab and 2 more

2 registry-linked trialsOpen access · goldAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 45 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 6 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01894113 nacompletednot on this map

Prospective, Randomised Multicenter Study Comparing Transbronchial Forceps Biopsy With Cryobiopsy in Interstitial Lung Disease

TypeinterventionalSponsorUniversity Hospital TuebingenRan2012 to 2014Enrolled382ConditionsInterstitial Lung DiseaseArmstransbronchial lung biopsy
NCT06266546 phase3active not recruitingnot on this mapstarted 2024, after this paper: background citation

Prophylactic Endobronchial Tranexamic Acid to Reduce Bleeding in Transbronchial Cryobiopsy

TypeinterventionalSponsorYoussef YammineRan2024 to 2028Enrolled100ConditionsHemorrhage Lung, Endobronchial MassArmsTranexamic acid
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 6 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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  2. Yield and safety of different biopsy types in interstitial lung disease: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
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  17. Central European journal of urology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Juergen HetzelDepartment of Haematology, Oncology, Rheumatology, Immunology and Pulmology, Eberhard Karls University, Otfried-Mueller-Str. 10, 70771, Tübingen, Germany. juergen.hetzel@med.uni-tuebingen.de.
Ralf EberhardtDepartment of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg and Translational Lung Research Center Heidelberg (TLRCH, German Center for Lung Research (DZL), Heidelberg, Germany.
Christoph PetermannDepartment for Pulmonary Diseases, Asklepios-Klinik Harburg, Hamburg, Germany.
Wolfgang GesierichLung Center Munich West, Helios Klinik Munich West, Munich, Germany.
Kaid DarwicheDepartment of Interventional Pneumology, Ruhrlandklinik, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany.
Lars HagmeyerClinic for Pneumology and Allergology, Center of Sleep Medicine and Respiratory Care, Bethanien Hospital, Solingen, Germany.
Rainer MucheInstitute of Epidemiology and Medical Biometry, Ulm University Ulm, Ulm, Germany.
Michael KreuterDepartment of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg and Translational Lung Research Center Heidelberg (TLRCH, German Center for Lung Research (DZL), Heidelberg, Germany.
Richard LewisNPARU, University of Worcester, Worcester, UK.
Ahmed EhabDepartment of Haematology, Oncology, Rheumatology, Immunology and Pulmology, Eberhard Karls University, Otfried-Mueller-Str. 10, 70771, Tübingen, Germany.
Michael BoeckelerDepartment of Haematology, Oncology, Rheumatology, Immunology and Pulmology, Eberhard Karls University, Otfried-Mueller-Str. 10, 70771, Tübingen, Germany.
Maik HaentschelDepartment of Haematology, Oncology, Rheumatology, Immunology and Pulmology, Eberhard Karls University, Otfried-Mueller-Str. 10, 70771, Tübingen, Germany.
University of Tübingen · DEHeidelberg University · DEAsklepios Klinikum Harburg · DEKrankenhaus Bethanien · DEUniversität Ulm · DEUniversity of Duisburg-Essen · DEUniversity of Worcester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBronchoscopic cryobiopsy is a new method of bronchoscopic tissue sampling in interstitial lung disease. In case of transbronchial biopsies, the resultant tissue samples are of high quality, and the lung parenchyma seen in the samples is adequate for a histological diagnosis in most cases. Bleeding after transbronchial biopsy is the most important procedure- associated complication and may be life threatening. This study addresses the risk of bleeding of transbronchial cryobiopsy.

methodsIn this prospective, randomized, controlled multicentre study 359 patients with interstitial lung disease requiring diagnostic bronchoscopic tissue sampling were included. Both conventional transbronchial forceps biopsy and transbronchial cryobiopsy were undertaken in each patient. The sequence of the procedures was randomized. Bleeding severity was evaluated semi-quantitatively as "no bleeding", "mild" (suction alone), "moderate" (additional intervention) or "severe" (prolonged monitoring necessary or fatal outcome), for each intervention.

resultsIn 359 patients atotal of 1160 cryobiopsies and 1302 forceps biopsies were performed. Bleeding was observed after forceps biopsy in 173 patients (48.2%) and after cryobiopsy in 261 patients (72.7%). Bleeding was significantly greater in the cryobiopsy group (cryobiopsy/forceps biopsy: no bleeding 27.3%/51.8%; mild 56.5%/44.0%; moderate 15.0%/4.2%; severe 1.2%/0%; p < 0.001). The rate of clinically relevant bleeding (moderate or severe) was higher after the cryobiopsy procedures compared to the forceps biopsies (16.2% vs. 4.2%, p < 0.05). No fatal bleeding complications occurred.

conclusionsCompared to transbronchial forceps biopsy, transbronchial cryobiopsy was associated with an increased risk of bleeding which is of clinical relevance. Therefore training and additional precautions for bleeding control should be considered.

trial registrationThe study was registered with clinicaltrials.gov ( NCT01894113 ).

Indexed as

AgedBiopsyBronchiCross-Over StudiesCryosurgeryFemaleHemorrhageHumansLung Diseases, InterstitialMaleMiddle AgedProspective StudiesRisk FactorsSurgical InstrumentsBleeding riskCryobiopsyForceps biopsyInterstitial lung diseaseRandomized prospective multicenter trial

Identifiers

PMID31277659
PMCPMC6612220
OpenAlexW2954048310

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.