ArticleLife (Basel, Switzerland)2019
Formation of Abasic Oligomers in Nonenzymatic Polymerization of Canonical Nucleotides.
Article in Life (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Wet-dry cycles cause nucleic acid monomers to polymerize into long chains.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context.iScience · 2023Article
- Distinguishing Biotic vs. Abiotic Origins of 'Bio'signatures: Clues from Messy Prebiotic Chemistry for Detection of Life in the Universe.Life (Basel, Switzerland) · 2023Article
- Catalytic Synthesis of Polyribonucleic Acid on Prebiotic Rock Glasses.Astrobiology · 2022Article
- Acid-Catalyzed RNA-Oligomerization from 3',5'-cGMP.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Questions and Answers Related to the Prebiotic Production of Oligonucleotide Sequences from 3',5' Cyclic Nucleotide Precursors.Life (Basel, Switzerland) · 2021Review
- Prebiotic oligomerization and self-assembly of structurally diverse xenobiological monomers.Scientific reports · 2020Article
- The Hot Spring Hypothesis for an Origin of Life.Astrobiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polymerization of nucleotides under prebiotically plausible conditions has been a focus of several origins of life studies. Non-activated nucleotides have been shown to undergo polymerization under geothermal conditions when subjected to dry-wet cycles. They do so by a mechanism similar to acid-catalyzed ester-bond formation. However, one study showed that the low pH of these reactions resulted in predominantly depurination, thereby resulting in the formation of abasic sites in the oligomers. In this study, we aimed to systematically characterize the nature of the oligomers that resulted in reactions that involved one or more of the canonical ribonucleotides. All the reactions analyzed showed the presence of abasic oligomers, with purine nucleotides being affected the most due to deglycosylation. Even in the reactions that contained nucleotide mixtures, the presence of abasic oligomers was detected, which suggested that information transfer would be severely hampered due to losing the capacity to base pair via H-bonds. Importantly, the stability of the
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.