Evidence map›Paper›PMID 31277411›Full record

ArticleCells2019

Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis.

Yoon Seon Oh, Eric J Wang, Casey D Gailey, David L Brautigan, Benjamin L Allen, Zheng Fu

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
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  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Modulation of Primary Cilia by Alvocidib Inhibition of CILK1.International journal of molecular sciences · 2022
    Article
  14. Review
  15. Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function.Developmental dynamics : an official publication of the American Association of Anatomists · 2021
    Article
  16. Article
  17. Intraflagellar transport trains and motors: Insights from structure.Seminars in cell & developmental biology · 2020
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yoon Seon OhDepartment of Pharmacology, University of Virginia Medical School, Charlottesville, VA 22908, USA.
Eric J WangDepartment of Pharmacology, University of Virginia Medical School, Charlottesville, VA 22908, USA.ORCID 0000-0002-6102-7421
Casey D GaileyDepartment of Pharmacology, University of Virginia Medical School, Charlottesville, VA 22908, USA.
David L BrautiganDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia Medical School, Charlottesville, VA 22908, USA.
Benjamin L AllenDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Zheng FuDepartment of Pharmacology, University of Virginia Medical School, Charlottesville, VA 22908, USA. zf6n@virginia.edu.
University of Virginia · USUniversity of Michigan · US

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Jay William FOX · 1987 to 2026
$72.1M
Signaling Mechanisms and Cellular Functions of a Ciliopathy-Associated Protein KinaseR01GM127690 · NIGMS · UNIVERSITY OF VIRGINIA · PI Zheng Fu · 2018 to 2026
$2.4M
Dosage-Dependent Hedgehog Signaling in Pancreatic CancerR01CA198074 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN, PASCA DI MAGLIANO, MARINA · 2015 to 2019
$1.9M
Kinesin-2 Regulation of GLI Function in Hedgehog Signal TransductionR01GM118751 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN · 2016 to 2019
$1.3M
NCI NIH HHS P30 CA044579NCI NIH HHS R01 CA198074NIGMS NIH HHS R01 GM118751NIGMS NIH HHS R01 GM127690
6 · The paper itself

Abstract

Loss-of-function mutations in the human

Indexed as

AnimalsCiliaHEK293 CellsHumansKinesinsMiceNIH 3T3 CellsPhosphorylationProtein DomainsProtein Serine-Threonine KinasesCILK1 protein, humanKIF3A protein, humanKinesinsProtein Serine-Threonine Kinasesand phosphorylationciliogenesisciliopathyciliopathy-associated protein kinaseintestinal cell kinasekinesin family member 3Aprimary cilia

Identifiers

PMID31277411
PMCPMC6678984
OpenAlexW2954846241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.