Evidence map›Paper›PMID 31277379›Full record

ArticleInternational journal of molecular sciences2019

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes.

Georg Auburger, Suzana Gispert, Sylvia Torres-Odio, Marina Jendrach, Nadine Brehm, Júlia Canet-Pons, Jana Key, Nesli-Ece Sen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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  6. Article
  7. Review
  8. Article
  9. Understanding the Potential of Genome Editing in Parkinson's Disease.International journal of molecular sciences · 2021
    Review
  10. Article
  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Georg AuburgerExperimental Neurology, Goethe University Medical Faculty, 60590 Frankfurt am Main, Germany. auburger@em.uni-frankfurt.de.
Suzana GispertExperimental Neurology, Goethe University Medical Faculty, 60590 Frankfurt am Main, Germany. gispert-sanchez@em.uni-frankfurt.de.
Sylvia Torres-OdioExperimental Neurology, Goethe University Medical Faculty, 60590 Frankfurt am Main, Germany. torresodio@medicine.tamhsc.edu.
Marina JendrachExperimental Neurology, Goethe University Medical Faculty, 60590 Frankfurt am Main, Germany. marina.jendrach@charite.de.
Nadine BrehmExperimental Neurology, Goethe University Medical Faculty, 60590 Frankfurt am Main, Germany. nadine.brehm85@googlemail.com.
Júlia Canet-PonsExperimental Neurology, Goethe University Medical Faculty, 60590 Frankfurt am Main, Germany. jcanetpons@gmail.com.
Jana KeyExperimental Neurology, Goethe University Medical Faculty, 60590 Frankfurt am Main, Germany. key@stud.uni-frankfurt.de.
Nesli-Ece SenExperimental Neurology, Goethe University Medical Faculty, 60590 Frankfurt am Main, Germany. nesliecesen@gmail.com.
Goethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hereditary Parkinson's disease (PD) can be triggered by an autosomal dominant overdose of alpha-Synuclein (SNCA) as stressor or the autosomal recessive deficiency of PINK1 Serine/Threonine-phosphorylation activity as stress-response. We demonstrated the combination of PINK1-knockout with overexpression of SNCA

Indexed as

AutophagyAgingalpha-SynucleinAmino Acid SequenceAnimalsAnkyrinsBrainMice, KnockoutMice, Mutant StrainsMicrotubule-Associated ProteinsMicrotubulesPhosphoproteinsPhosphorylationPhosphoserinePhosphothreonineProtein Domainsalpha-SynucleinAnk2 protein, mouseAnkyrinsmicrotubule-associated protein 1BMicrotubule-Associated ProteinsPhosphoproteinsPhosphoserinePhosphothreonineProtein KinasesProteomePTEN-Induced Putative KinaseSnca protein, mousealpha-synucleinautophagybrain phosphorylomemicrotubular cytoskeletonParkinson’s diseasePINK1synaptic signaling

Identifiers

PMID31277379
PMCPMC6651490
OpenAlexW2948868528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.