ArticleInternational journal of environmental research and public health2019
Smoking-Related DNA Methylation is Associated with DNA Methylation Phenotypic Age Acceleration: The Veterans Affairs Normative Aging Study.
Article in International journal of environmental research and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Biological aging acceleration associated with electronic cigarette use in the United States.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study.Clinical epigenetics · 2026Article
- Review
- Associations of volatile organic compounds with accelerated epigenetic aging in the lungs of smokers and electronic cigarette users.The Science of the total environment · 2025Article
- Multiplexing and massive parallel sequencing of targeted DNA methylation to predict chronological age.Frontiers in aging · 2025Article
- Phenotypic age mediates effects of Life's Essential 8 on reduced mortality risk in US adults.Precision clinical medicine · 2024Article
- Article
- Race and Ethnicity, Socioeconomic Factors, and Epigenetic Age Acceleration in Survivors of Childhood Cancer.JAMA network open · 2024Article
- Diagnostic classification based on DNA methylation profiles using sequential machine learning approaches.PloS one · 2024Article
- Article
- Inequalities in urban greenness and epigenetic aging: Different associations by race and neighborhood socioeconomic status.Science advances · 2023Article
- Prediction of chronological age and its applications in forensic casework: methods, current practices, and future perspectives.Forensic sciences research · 2023Review
- Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults.Clinical epigenetics · 2022Article
- Epigenome-wide association study and epigenetic age acceleration associated with cigarette smoking among Costa Rican adults.Scientific reports · 2022Article
- DNA Methylation Aberrant in Atherosclerosis.Frontiers in pharmacology · 2022Review
- DNA methylation-based surrogates of plasma proteins are associated with Parkinson's disease risk.Journal of the neurological sciences · 2021Article
- Systems toxicology study reveals reduced impact of heated tobacco product aerosol extract relative to cigarette smoke on premature aging and exacerbation effects in aged aortic cells in vitro.Archives of toxicology · 2021Article
- DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function.Clinical epigenetics · 2021Article
- Article
- Epigenetic clocks may come out of rhythm-implications for the estimation of chronological age in forensic casework.International journal of legal medicine · 2020Review
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation may play a critical role in aging and age-related diseases. DNA methylation phenotypic age (DNAmPhenoAge) is a new aging biomarker and predictor of chronic disease risk. While smoking is a strong risk factor for chronic diseases and influences methylation, its influence on DNAmPhenoAge is unknown. We investigated associations of self-reported and epigenetic smoking indicators with DNAmPhenoAge acceleration in a longitudinal aging study in eastern Massachusetts. DNA methylation was measured in whole blood samples from multiple visits for 692 male participants in the Veterans Affairs Normative Aging Study during 1999-2013. Acceleration was defined using residuals from linear regression of the DNAmPhenoAge on the chronological age. Cumulative smoking (pack-years) was significantly associated with DNAmPhenoAge acceleration, whereas self-reported smoking status was not. We observed significant validated associations between smoking-related loci and DNAmPhenoAge acceleration for 52 CpG sites, where 18 were hypomethylated and 34 were hypermethylated, mapped to 16 genes. The
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.