Evidence map›Paper›PMID 31277180›Full record

ArticleMedicine2019

Maternal depression treatment in HIV (M-DEPTH): Study protocol for a cluster randomized controlled trial.

Glenn J Wagner, Ryan K McBain, Dickens Akena, Victoria Ngo, Janet Nakigudde, Juliet Nakku, Harriet Chemusto, Jolly Beyeza-Kashesya, Violet Gwokyalya, Laura J Faherty and 8 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03892915 (Depression Care to Improve Adherence to Prevention of Mother-to-Child-Transmission), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03892915 phase2 / phase3completednot on this map

Depression Care to Improve Adherence to Prevention of Mother-to-Child-Transmission (PMTCT) Care Continuum & Pregnancy Outcomes

TypeinterventionalSponsorRANDRan2019 to 2024Enrolled391ConditionsDepressionArmsevidence-based depression treatment
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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  15. Mental Health in Women Living With HIV: The Unique and Unmet Needs.Journal of the International Association of Providers of AIDS Care
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 2 countries.

Glenn J WagnerRAND Corporation, Santa Monica, CA.
Ryan K McBainRAND Corporation, Santa Monica, CA.
Dickens AkenaMakerere University, Kampala, Uganda.
Victoria NgoRAND Corporation, Santa Monica, CA.
Janet NakiguddeMakerere University, Kampala, Uganda.
Juliet NakkuMakerere University, Kampala, Uganda.
Harriet ChemustoMildmay Uganda, Kampala, Uganda.
Jolly Beyeza-KashesyaMakerere University, Kampala, Uganda.
Violet GwokyalyaMakerere University, Kampala, Uganda.
Laura J FahertyRAND Corporation, Santa Monica, CA.
Leticia KyohangirweMakerere University, Kampala, Uganda.
Linda Kisaakye NabitakaMinistry of Health, Uganda.
Hafsa LukwataMinistry of Health, Uganda.
Sebastian LinnemayrRAND Corporation, Santa Monica, CA.
Bonnie Ghosh-DastidarRAND Corporation, Santa Monica, CA.
Juliet BusingeMildmay Uganda, Kampala, Uganda.
Barbara MukasaMildmay Uganda, Kampala, Uganda.
Rhoda K WanyenzeMakerere University, Kampala, Uganda.
Makerere University · UGRAND Corporation · USMildmay Uganda · UGMinistry of Health · UGBoston University · USCity University of New York · US

Funding

Depression Care to Improve Adherence to PMTCT Care Continuum & Pregnancy OutcomesR01MH115830 · NIMH · RAND CORPORATION · PI WAGNER, GLENN JOHN · 2018 to 2022
$3.1M
NIMH NIH HHS R01 MH115830
6 · The paper itself

Abstract

introductionOver one-third of human immunodeficiency virus (HIV)-infected pregnant women are clinically depressed, increasing the risk of mother-to-child transmission (MTCT) of HIV, as well as negative birth and child development outcomes. This study will evaluate the efficacy and cost-effectiveness of an evidence-based stepped care treatment model for perinatal depression (maternal depression treatment in HIV [M-DEPTH]) to improve adherence to prevention of MTCT care among HIV+ women in Uganda.

methodsEight antenatal care (ANC) clinics in Uganda will be randomized to implement either M-DEPTH (n=4) or usual care (n=4) for perinatal depression among 400 pregnant women (n=50 per clinic) between June 2019 and August 2022. At each site, women who screen positive for potential depression will be enrolled and followed for 18 months post-delivery, assessed in 6-month intervals: baseline, within 1 month of child delivery or pregnancy termination, and months 6, 12, and 18 following delivery. Primary outcomes include adherence to the prevention of mother-to-child transmission (PMTCT) care continuum-including maternal antiretroviral therapy and infant antiretrovial prophylaxis, and maternal virologic suppression; while secondary outcomes will include infant HIV status, post-natal maternal and child health outcomes, and depression treatment uptake and response. Repeated-measures multivariable regression analyses will be conducted to compare outcomes between M-DEPTH and usual care, using 2-tailed tests and an alpha cut-off of P <.05. Using a micro-costing approach, the research team will relate costs to outcomes, examining the incremental cost-effectiveness ration (ICER) of M-DEPTH relative to care as usual. DISCUSSION: This cluster randomized controlled trial will be one of the first to compare the effects of an evidence-based depression care model versus usual care on adherence to each step of the PMTCT care continuum. If determined to be efficacious and cost-effective, this study will provide a model for integrating depression care into ANC clinics and promoting adherence to PMTCT.

trial registrationNIH Clinical Trial Registry NCT03892915 (clinicaltrials.gov).

Indexed as

Prenatal CareAdolescentAdultAnti-HIV AgentsDepressive DisorderFemaleHIV InfectionsHumansInfectious Disease Transmission, VerticalPregnancyPregnancy Complications, InfectiousRandomized Controlled Trials as TopicUgandaYoung AdultAnti-HIV Agents

Identifiers

PMID31277180
PMCPMC6635242
OpenAlexW2957118386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.