Evidence map›Paper›PMID 31276933›Full record

ArticleNeoplasia (New York, N.Y.)2019

Downregulation of Notch Signaling in Kras-Induced Gastric Metaplasia.

Wen-Cheng Chung, Yunyun Zhou, Azeddine Atfi, Keli Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neoplasia (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Recent advances in spasmolytic polypeptide expressing metaplasia research.World journal of gastrointestinal oncology · 2026
    Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Wen-Cheng ChungCancer Institute, University of Mississippi Medical Center, Jackson, MS, USA.
Yunyun ZhouDepartment of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
Azeddine AtfiCellular and Molecular Pathogenesis Division, Department of Pathology, Virginia Commonwealth University, Richmond, VA, USA.
Keli XuCancer Institute, University of Mississippi Medical Center, Jackson, MS, USA; Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS, USA. Electronic address: kxu@umc.edu.
University of Mississippi Medical Center · USJackson Memorial Hospital · USVirginia Commonwealth University · US

Funding

Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Ashley C. Johnson, Babbette LaMarca · 2017 to 2026
$26.4M
NIGMS NIH HHS P20 GM121334
6 · The paper itself

Abstract

Activating mutations and amplification of Kras and, more frequently, signatures for Kras activation are noted in stomach cancer. Expression of mutant Kras

Indexed as

Signal TransductionAnimalsBasic Helix-Loop-Helix ProteinsBiomarkers, TumorCarcinoma, Squamous CellCell Line, TumorCell ProliferationCell Transformation, NeoplasticDisease Models, AnimalGastric MucosaHumansHyperplasiaImmunohistochemistryJagged-1 ProteinMetaplasiaMiceBasic Helix-Loop-Helix ProteinsBhlha15 protein, mouseBiomarkers, TumorJagged-1 ProteinKRAS protein, humanProto-Oncogene Proteins p21(ras)Receptors, Notch

Identifiers

PMID31276933
PMCPMC6611983
OpenAlexW2955495694

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.