Evidence map›Paper›PMID 31276654›Full record

ArticleJournal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons2019

Severe Sleep Apnea Associated With Increased Systemic Inflammation and Decreased Serum Bilirubin.

Arthur H Friedlander, Kristina I Boström, Hoang-Anh Tran, Tina I Chang, John C Polanco, Urie K Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Bilirubin as a metabolic hormone: the physiological relevance of low levels.American journal of physiology. Endocrinology and metabolism · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Arthur H FriedlanderAssociate Chief of Staff and Director, Department of Graduate Medical Education, Veterans Affairs Greater Los Angeles Healthcare System; Director, Quality Assurance Hospital Dental Service, Ronald Reagan UCLA Medical Center; and Professor-in-Residence, Department of Oral and Maxillofacial Surgery, University of California, Los Angeles, School of Dentistry, Los Angeles, CA. Electronic address: arthur.friedlander@va.gov.
Kristina I BoströmChief, Department of Cardiology, Veterans Affairs Greater Los Angeles Healthcare System; and Professor, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA and Molecular Biology Institute, University of California, Los Angeles, CA.
Hoang-Anh TranJunior Oral and Maxillofacial Surgery Veterans Affairs Special Fellow, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA.
Tina I ChangDirector, Research Fellowship and Inpatient Oral and Maxillofacial Surgery, Veterans Affairs Great Los Angeles Healthcare System; and Instructor, Department of Oral and Maxillofacial Surgery, University of California, Los Angeles, School of Dentistry, Los Angeles, CA.
John C PolancoResearch Fellow, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA.
Urie K LeeSenior Oral and Maxillofacial Surgery Veterans Affairs Special Fellow, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA.
VA Greater Los Angeles Healthcare System · USBeth Israel Deaconess Medical Center · USUniversity of California, Los Angeles · US

Funding

Molecular Mechanisms of MGP; Role in AVMsR01HL081397 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOSTROM, KRISTINA I · 2006 to 2025
$7.7M
NHLBI NIH HHS R01 HL081397
6 · The paper itself

Abstract

purposeObstructive sleep apnea hypopnea syndrome (OSAHS) among older men has been associated with increased systemic inflammation, as evidenced by an increased neutrophil/lymphocyte ratio (NLR) and provocation of coronary artery atherosclerosis, potentially resulting in myocardial infarction (MI). The total serum bilirubin levels (TSBLs; formed primarily from senescent red blood cells via the catabolic pathway in the reticuloendothelial system) at the higher end of the normal reference range are anti-inflammatory. However, at the lower end of the physiologic range, they have been associated with increased adverse vascular events. We compared the relationship between NLR and TSBL among subjects with "severe" OSAHS. MATERIALS AND

methodsWe used a retrospective, cross-sectional study design. The electronic medical records of older male subjects (age range, 55 to 74 years) with "severe" OSAHS treated by the dental service (January 1, 2017 to December 31, 2017) were examined. The predictor variable was the NLR, and the outcome variable was the TSBL; both were analyzed using continuous scales. Spearman's rank order correlation analysis explicated the relationship between the NLR and TBSL. Traditional proatherogenic risk factors (ie, age, body mass index, hypertension, hyperlipidemia, diabetes) were evaluated for independence using descriptive and logistic regression analysis. Significance was set at P = .05 for all tests.

resultsA total sample size of 47 subjects (mean age, 63.74 ± 4.12 years) was enrolled in the present study. The Spearman rank order correlation analysis determined that the NLR is significantly (P = .038) and inversely related to the TSBL (r

conclusionsOlder men with "severe" OSAHS demonstrated an inverse relationship between NLR and TSBL. This combination of a heightened severity marker of systemic inflammation (ie, elevated NLR) and an indicator of amplified atherosclerotic activity (ie, diminished TSBL) will identify patients potentially at increased risk of future MI and the need for cardiovascular evaluation.

Indexed as

BilirubinInflammationSleep Apnea, ObstructiveAgedCross-Sectional StudiesHumansMaleMiddle AgedRetrospective StudiesBilirubin

Identifiers

PMID31276654
PMCPMC12915543
OpenAlexW2952856789

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.