Evidence map›Paper›PMID 31276622›Full record

ArticleACS combinatorial science2019

Encrypted Oligonucleotide Arrays for Molecular Authentication.

Matthew T Holden, Lloyd M Smith

Abstract read
In one paragraph

Article in ACS combinatorial science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Matthew T HoldenDepartment of Chemistry , University of Wisconsin-Madison , 1101 University Avenue , Madison , Wisconsin 53706 , United States.ORCID 0000-0001-5430-7268
Lloyd M SmithDepartment of Chemistry , University of Wisconsin-Madison , 1101 University Avenue , Madison , Wisconsin 53706 , United States.

Funding

BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
Functional characterization of regulatory sequence variants in complex diseasesR01GM109099 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI OLIVIER, MICHAEL · 2014 to 2017
$2.6M
Development and Applications of High Density RNA ArraysR01GM108727 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI SMITH, LLOYD M · 2014 to 2017
$1.1M
NIGMS NIH HHS R01 GM108727NIGMS NIH HHS R01 GM109099NIGMS NIH HHS T32 GM008349
6 · The paper itself

Abstract

Counterfeiting is an incredibly widespread problem, with some estimates placing its economic impact above 2% of worldwide GDP. The scale of the issue suggests that current preventive measures are either technologically insufficient or too impractical and costly to be widely adopted. High-density arrays of biomolecules are explored here as security devices that can be coupled to a valuable commodity as proof of its authenticity. Light-directed DNA array fabrication technology is used to synthesize arrays that are designed to resist analysis with sequencing-by-hybridization approaches. A relatively simple sequence design strategy forces a counterfeiter to undertake a prohibitively high number of complex experiments to decipher the array sequences employed.

Indexed as

Nucleic Acid HybridizationOligonucleotide Array Sequence AnalysisCombinatorial Chemistry TechniquesDNADNAAnticounterfeitingAuthenticationEncryptionMaskless array synthesisPhotolithography

Identifiers

PMID31276622
PMCPMC6701472

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.