Evidence map›Paper›PMID 31276432›Full record

ArticleRNA biology2019

Conserved microRNA mediates heating tolerance in germ cells versus surrounding somatic cells.

Yi Wu, Yingzheng Wang, Qiang Liu, Lihua Julie Zhu, Hui Gao, Maosheng Cui, Jinghao Liu, Pengju Zhao, Jianfeng Liu, Lei Chen and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 3 countries.

Yi WuNational Engineering Laboratory for Animal Breeding; Key Laboratory of Animal Genetics, Breeding, and Reproduction of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University , Beijing , China.
Yingzheng WangNational Engineering Laboratory for Animal Breeding; Key Laboratory of Animal Genetics, Breeding, and Reproduction of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University , Beijing , China.
Qiang LiuNational Engineering Laboratory for Animal Breeding; Key Laboratory of Animal Genetics, Breeding, and Reproduction of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University , Beijing , China.
Lihua Julie ZhuMolecular, Cell and Cancer Biology, Program in Molecular Medicine, Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School , Worcester , MA , USA.
Hui GaoNational Engineering Laboratory for Animal Breeding; Key Laboratory of Animal Genetics, Breeding, and Reproduction of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University , Beijing , China.
Maosheng CuiBiotechnology Laboratory of Animal Reproduction, Tianjin Academy of Animal Science , Tianjin , China.
Jinghao LiuLaboratory Animal Center, Peking University , Beijing , China.
Pengju ZhaoNational Engineering Laboratory for Animal Breeding; Key Laboratory of Animal Genetics, Breeding, and Reproduction of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University , Beijing , China.
Jianfeng LiuNational Engineering Laboratory for Animal Breeding; Key Laboratory of Animal Genetics, Breeding, and Reproduction of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University , Beijing , China.
Lei ChenKey Laboratory of Pig Industry Sciences (Ministry of Agriculture), Chongqing Academy of Animal Science , Chongqing , China.
Jinyong WangKey Laboratory of Pig Industry Sciences (Ministry of Agriculture), Chongqing Academy of Animal Science , Chongqing , China.
Wenxian ZengCollege of Animal Science and Technology, Northwest A&F University , Shaanxi , China.
Teresa K WoodruffDivision of Fertility Preservation, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University , Chicago , IL , USA.ORCID 0000-0002-1197-3399
Shenming ZengNational Engineering Laboratory for Animal Breeding; Key Laboratory of Animal Genetics, Breeding, and Reproduction of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University , Beijing , China.
China Agricultural University · CNChongqing Academy of Animal Science · CNPeking University · CNCapital Medical University · CNNorthwest A&F University · CNNorthwestern University · USTianjin Academy of Agricultural Sciences · CNUniversity of Massachusetts Chan Medical School · US

Funding

Transition Metal Regulation of Oocyte MaturationP01HD021921 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MAYO, KELLY E · 1987 to 2013
$18.5M
NICHD NIH HHS P01 HD021921
6 · The paper itself

Abstract

Mammalian fertility is reduced during heat exposure in the summer, but is regained as temperatures decrease in the autumn again. However, the mechanism underlying the phenomenon remains unknown. We investigated heat stress tolerance of germ cells and their surrounding somatic cells, and discovered that microRNA ssc-ca-1 was upregulated after heat stress in cultured porcine granulosa cells (GCs), but not in serum-starved GCs. Ssc-ca-1 inhibited heat shock protein 70 (Hsp70) expression through its 3'- and 5'-UTRs. Although

Indexed as

AnimalsApoptosisBiomarkersFemaleGene Expression RegulationGerm CellsGranulosa CellsHeat-Shock ResponseHSP70 Heat-Shock ProteinsMaleMicroRNAsOvarian FollicleSertoli CellsSwineThermotoleranceBiomarkersHSP70 Heat-Shock ProteinsMicroRNAsheat stressMicroRNAprimordial folliclespermatogonial stem cells

Identifiers

PMID31276432
PMCPMC6779383
OpenAlexW2955327998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.