ArticleAnalytical chemistry2019
Multilayered Microfluidic Paper-Based Devices: Characterization, Modeling, and Perspectives.
Article in Analytical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Revolutionizing Healthcare With Paper-Based Nucleic Acid Testing.Exploration (Beijing, China) · 2026Review
- Sponge-Based Flow Control in Laminate Capillary-Driven Electrochemical Microfluidic Devices for Viscous Sample Analysis.Analytical chemistry · 2026Article
- Paper-Based Microfluidic Chips for At-Home Point-of-Care Nucleic Acid Testing: Applications and Challenges.Diagnostics (Basel, Switzerland) · 2026Review
- Advancing Women's Performance in Fitness and Sports: An Exploratory Field Study on Hormonal Monitoring and Menstrual Cycle-Tailored Training Strategies.Sports (Basel, Switzerland) · 2026Article
- Hydroelectricity Generation from Fiber-Oriented Waste Paper via Capillary-Driven Charge Separation.Polymers · 2025Article
- Paper-Based Fast-Flow Electrochemical Device Enabling Self-Calibrated and High-Throughput NADPH Measurements.Analytical chemistry · 2025Article
- Fluid Flow Dynamics in Partially Saturated Paper.Micromachines · 2024Article
- Enhanced capillary pumping using open-channel capillary trees with integrated paper pads.Physics of fluids (Woodbury, N.Y. : 1994) · 2023Article
- Article
- Maximizing flow rate in single paper layer, rapid flow microfluidic paper-based analytical devices.Microfluidics and nanofluidics · 2023Article
- Simple manipulation of enzyme-linked immunosorbent assay (ELISA) using an automated microfluidic interface.Analytical methods : advancing methods and applications · 2022Article
- Controlling Capillary Flow Rate on Lateral Flow Test Substrates by Tape.Micromachines · 2021Article
- Flow control in a laminate capillary-driven microfluidic device.The Analyst · 2021Article
- Microfluidic and Microscale Assays to Examine Regenerative Strategies in the Neuro Retina.Micromachines · 2020Review
- Paper-based pump-free magnetophoresis.Analytical methods : advancing methods and applications · 2020Article
- Disposable glassy carbon stencil printed electrodes for trace detection of cadmium and lead.Analytica chimica acta · 2020Article
- Paper Stacks for Uniform Rehydration of Dried Reagents in Paper Microfluidic Devices.Scientific reports · 2019Article
- Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices.Molecules (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Microfluidic paper-based analytical devices (μPADs) are simple but powerful analytical tools that are gaining significant recent attention due to their many advantages over more traditional monitoring tools. These include being inexpensive, portable, pump-free, and having the ability to store reagents. One major limitation of these devices is slow flow rates, which are controlled by capillary action in the hydrophilic pores of cellulosic paper. Recent investigations have advanced the flow rates in μPADs through the generation of a gap or channel between two closely spaced paper sheets. This multilayered format has opened up μPADs to new applications and detection schemes, where large gap sizes (>300 μm) provide at least 169× faster flow rates than single-layer μPADs, but do not conform to established mathematical models for fluid transport in porous materials, such as the classic Lucas-Washburn equation. In the present study, experimental investigations and analytical modeling are applied to elucidate the driving forces behind the rapid flow rates in these devices. We investigate a range of hypotheses for the systems fluid dynamics and establish a theoretical model to predict the flow rate in multilayered μPADs that takes into account viscous dissipation within the paper. Device orientation, sample addition method, and the gap height are found to be critical concerns when modeling the imbibition in multilayered devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.