Evidence map›Paper›PMID 31276263›Full record

ArticleJournal of magnetic resonance imaging : JMRI2020

Evaluation of a motion-robust 2D chemical shift-encoded technique for R2* and field map quantification in ferumoxytol-enhanced MRI of the placenta in pregnant rhesus macaques.

Ante Zhu, Scott B Reeder, Kevin M Johnson, Sydney M Nguyen, Thaddeus G Golos, Ann Shimakawa, Matthias R Muehler, Christopher J Francois, Ian M Bird, Sean B Fain and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Ante ZhuDepartment of Biomedical Engineering, University of Wisconsin, Madison, Wisconsin, USA.ORCID 0000-0001-6251-2341
Scott B ReederDepartment of Biomedical Engineering, University of Wisconsin, Madison, Wisconsin, USA.
Kevin M JohnsonDepartment of Radiology, University of Wisconsin, Madison, Wisconsin, USA.
Sydney M NguyenWisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin, USA.
Thaddeus G GolosWisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin, USA.
Ann ShimakawaGlobal MR Applications and Workflow, GE Healthcare, Menlo Park, California, USA.
Matthias R MuehlerDepartment of Radiology, University of Wisconsin, Madison, Wisconsin, USA.
Christopher J FrancoisDepartment of Radiology, University of Wisconsin, Madison, Wisconsin, USA.
Ian M BirdDepartment of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin, USA.
Sean B FainDepartment of Biomedical Engineering, University of Wisconsin, Madison, Wisconsin, USA.
Dinesh M ShahDepartment of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin, USA.
Oliver WiebenDepartment of Radiology, University of Wisconsin, Madison, Wisconsin, USA.
Diego HernandoDepartment of Biomedical Engineering, University of Wisconsin, Madison, Wisconsin, USA.
University of Wisconsin–Madison · USUniversity of Wisconsin System · USGeneral Electric (Spain) · ES

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Advanced MRI FOR Uteroplacental Flow, Perfusion, Oxygenation & InflammationU01HD087216 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI SHAH, DINESH MANILAL, WIEBEN, OLIVER · 2015 to 2015
$4.0M
Endocrinology-Reproductive Physiology Training GrantT32HD041921 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI BIRD, IAN M. · 2004 to 2022
$3.0M
Confounder-Corrected Quantitative MRI Biomarkers of HepaticR01DK100651 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2014 to 2017
$2.7M
MRI-based Quantitative Susceptibility Mapping of Hepatic Iron OverloadR01DK117354 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI HERNANDO, DIEGO · 2018 to 2021
$2.3M
Evolution of Quantitative MRI Biomarkers of Metabolic Syndrome During PubertyK24DK102595 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2014 to 2018
$927k
NICHD NIH HHS T32 HD041921NICHD NIH HHS U01 HD087216NIDDK NIH HHS K24 DK102595NIDDK NIH HHS R01 DK100651NIDDK NIH HHS R01 DK117354NIH HHS P51 OD011106
6 · The paper itself

Abstract

background3D chemical shift-encoded (CSE)-MRI techniques enable assessment of ferumoxytol concentration but are unreliable in the presence of motion. PURPOSE: To evaluate a motion-robust 2D-sequential CSE-MRI for R2* and B0 mapping in ferumoxytol-enhanced MRI of the placenta. STUDY TYPE: Prospective. ANIMAL MODEL: Pregnant rhesus macaques. FIELD STRENGTH/SEQUENCE: 3.0T/CSE-MRI. ASSESSMENT: 2D-sequential CSE-MRI was compared with 3D respiratory-gated CSE-MRI in placental imaging of 11 anesthetized animals at multiple timepoints before and after ferumoxytol administration, and in ferumoxytol phantoms (0 μg/mL-440 μg/mL). Motion artifacts of CSE-MRI in 10 pregnant women without ferumoxytol administration were assessed retrospectively by three blinded readers (4-point Likert scale). The repeatability of CSE-MRI in seven pregnant women was also prospectively studied. STATISTICAL TESTS: Placental R2* and boundary B0 field measurements (ΔB0) were compared between 2D-sequential and 3D respiratory-gated CSE-MRI using linear regression and Bland-Altman analysis.

resultsIn phantoms, a slope of 0.94 (r DATA

conclusion2D-sequential CSE-MRI provides accurate R2* and B0 measurements in ferumoxytol-enhanced placental MRI of animals in the presence of respiratory motion, and motion-robustness in human placental imaging. LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2020;51:580-592.

Indexed as

Ferrosoferric OxideMagnetic Resonance ImagingAnimalsFemaleHumansMacaca mulattaPlacentaPregnancyProspective StudiesReproducibility of ResultsRetrospective StudiesFerrosoferric OxideB0 fieldchemical shift-encodedferumoxytolmotion-robustplacentaR2*

Identifiers

PMID31276263
PMCPMC7839098
OpenAlexW2955808003

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.