Evidence map›Paper›PMID 31276233›Full record

ArticleAlcoholism, clinical and experimental research2019

Alcohol Consumption in Later Life and Mortality in the United States: Results from 9 Waves of the Health and Retirement Study.

Katherine M Keyes, Esteban Calvo, Katherine A Ornstein, Caroline Rutherford, Matthew P Fox, Ursula M Staudinger, Linda P Fried

Abstract read
In one paragraph

Article in Alcoholism, clinical and experimental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  10. Is drinking wine in moderation good for health or not?European heart journal supplements : journal of the European Society of Cardiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katherine M KeyesDepartment of Epidemiology, Columbia University, New York, New York.ORCID 0000-0002-5624-021X
Esteban CalvoDepartment of Epidemiology, Columbia University, New York, New York.
Katherine A OrnsteinDepartment of Geriatrics and Palliative Medicine, Icahn School of Medicine, New York, New York.
Caroline RutherfordDepartment of Epidemiology, Columbia University, New York, New York.
Matthew P FoxDepartments of Epidemiology and Global Health, Boston University, Boston, Massachusetts.
Ursula M StaudingerRobert N. Butler Columbia Aging Center, Columbia University, New York, New York.
Linda P FriedDepartment of Epidemiology, Columbia University, New York, New York.

Funding

Race, alcohol consumption and vehicle crashes: an epidemiologic paradoxK01AA021511 · NIAAA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KEYES, KATHERINE M. · 2013 to 2017
$904k
FONDECYT 1181009NIAAA NIH HHS K01 AA021511Robert N. Butler Columbia Aging Center
6 · The paper itself

Abstract

backgroundAlcohol consumption in later life has increased in the past decade, and the relationship between alcohol consumption and mortality is controversial. Recent studies suggest little, if any, health benefit to alcohol. Yet most rely on single-time point consumption assessments and minimal confounder adjustments.

methodsWe report on 16 years of follow-up from the Health and Retirement Study (HRS) cohorts born 1931 to 1941 (N = 7,904, baseline mean age = 61, SD = 3.18). Respondents were queried about drinking frequency/quantity. Mortality was established via exit interviews and confirmed with the national death index. Time-varying confounders included but were not limited to household assets, smoking, body mass index, health/functioning, depression, chronic disease; time-invariant confounders included baseline age, education, sex, and race.

resultsAfter adjustment, current abstainers had the highest risk of subsequent mortality, consistent with sick quitters, and moderate (men: HR = 0.74, 95% CI: 0.60 to 0.91; women: HR = 0.82, 95% CI: 0.63 to 1.07) drinking was associated with a lower mortality rate compared with occasional drinking, though smokers and men evidenced less of an inverse association. Quantitative bias analyses indicated that omitted confounders would need to be associated with ~4-fold increases in mortality rates for men and ~9-fold increases for women to change the results.

conclusionsThere are consistent associations between moderate/occasional drinking and lower mortality, though residual confounding remains a threat to validity. Continued efforts to conduct large-scale observational studies of alcohol consumption and mortality are needed to characterize the changing patterns of consumption in older age.

Indexed as

Alcohol DrinkingFemaleFollow-Up StudiesHumansMaleMiddle AgedRisk FactorsSex FactorsUnited StatesAlcohol ConsumptionHealth and Retirement StudyModerate DrinkingMortalityOlder Adults

Identifiers

PMID31276233
PMCPMC6677628

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.