Evidence map›Paper›PMID 31276202›Full record

ArticleInternational journal of cancer2020

Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3).

Joyce Y Huang, Tricia L Larose, Hung N Luu, Renwei Wang, Anouar Fanidi, Karine Alcala, Victoria L Stevens, Stephanie J Weinstein, Demetrius Albanes, Neil E Caporaso and 44 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

54 authors at 20 institutions in 10 countries.

Joyce Y HuangDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA.
Tricia L LaroseGenetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
Hung N LuuDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA.ORCID 0000-0002-2172-1849
Renwei WangDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA.
Anouar FanidiGenetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
Karine AlcalaGenetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
Victoria L StevensBehavior and Epidemiology Research Group, American Cancer Society, Inc., Atlanta, GA.
Stephanie J WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD.
Neil E CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD.
Mark P PurdueDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD.ORCID 0000-0003-1177-3108
Regina G ZieglerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD.
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD.
Ross L PrenticeDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
Mary PettingerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
Cynthia A ThomsonDepartment of Health Promotion Science, Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.
Jie WuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.
William J BlotDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0002-0711-8314
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0003-1226-070X
Alan A ArslanDepartment of Obstetrics and Gynecology, Population Health, Environmental Medicine and Perlmutter Cancer Center, New York University School of Medicine, New York, NY.
Anne Zeleniuch-JacquotteDepartment of Population Health and Environmental Medicine and Perlmutter Cancer Centre, New York University School of Medicine, New York, NY.
Loïc Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI.
Lynn R WilkensEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI.
Christopher A HaimanDepartment of Prevention, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Xuehong ZhangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.ORCID 0000-0002-8260-8508
Meir J StampferChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Jiali HanDepartment of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN.
Graham G GilesCancer Epidemiology and Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Allison M HodgeCancer Epidemiology and Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Gianluca SeveriCancer Epidemiology and Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Mikael JohanssonDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
Kjell GrankvistDepartment of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.
Arnulf LanghammerHUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway.
Kristian HveemK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health & Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Yong-Bing XiangState Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.ORCID 0000-0002-3840-9915
Hong-Lan LiDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Kala VisvanathanGeorge W. Comstock Center for Public Health Research and Prevention Health Monitoring Unit, Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Per M UelandDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Øivind MidttunBevital AS, Bergen, Norway.
Arve UlviBevital AS, Bergen, Norway.
Julie E BuringDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
I-Min LeeDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Howard D SessoDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA.
J Michael GazianoDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA.
Jonas ManjerDepartment of Surgery, Skåne University Hospital Malmö Lund University, Malmö, Sweden.
Caroline ReltonMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Woon-Puay KohHealth Services and Systems Research, Duke-NUS Medical School, Singapore.
Paul BrennanGenetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
Mattias JohanssonGenetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
Jian-Min YuanDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA.ORCID 0000-0002-4620-3108
Brigham and Women's Hospital · USNational Cancer Institute · USCentre international de recherche sur le cancer · FRVanderbilt University · USNorwegian University of Science and Technology · NOUniversity of Pittsburgh · USCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZAJohns Hopkins University · USNational University of Singapore · SGNew York University · USThe University of Melbourne · AUUniversity of Hawaiʻi at Mānoa · USAmerican Cancer Society · USBevital (Norway) · NOHaukeland University Hospital · NOInserm · FRLund University · SERenji Hospital · CNRichard M. Fairbanks Foundation · USShanghai Jiao Tong University · CN

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
Southern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0M
Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
RESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COSTA, MAX · 1985 to 2020
$26.1M
Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) StudyZIACP010195 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ALBANES, DEMETRIUS · 2009 to 2025
$22.5M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Southern Community Cohort StudyU01CA202979 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., SHRUBSOLE, MARTHA J. · 2016 to 2025
$22.0M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
Prospective studies of cancer etiology and prevention in Shanghai and SingaporeR01CA144034 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2010 to 2014
$7.0M
Shanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9M
Shanghai Men's Health StudyUM1CA173640 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHU, XIAO-OU · 2013 to 2017
$4.9M
NCI NIH HHS HHSN261201500005CNCI NIH HHS P01 CA087969NCI NIH HHS P30CA016087NCI NIH HHS R01 CA047988NCI NIH HHS R01 CA092447NCI NIH HHS R01CA144034NCI NIH HHS U01 CA155340NCI NIH HHS U01 CA182913NCI NIH HHS U01 CA202979NCI NIH HHS U01CA202979NCI NIH HHS UM1 CA167552NCI NIH HHS UM1CA167552NCI NIH HHS UM1 CA173640NCI NIH HHS UM1 CA182876NCI NIH HHS UM1CA182876NCI NIH HHS UM1 CA182910NCI NIH HHS UM1CA182910NCI NIH HHS UM1 CA182913NCI NIH HHS UM1 CA182934NCI NIH HHS UM1CA182934NCI NIH HHS UM1 CA186107NHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL080467NHLBI NIH HHS RC1 HL099355NIDA NIH HHS HHSN271201600004CNIDA NIH HHS HHSN271201600004INIH HHS CA047988NIH HHS CA097193NIH HHS CA34944NIH HHS CA40360NIH HHS HL043851NIH HHS HL080467NIH HHS HL099355NIH HHS HL26490NIH HHS HL34595NIH HHS P30ES000260World Health Organization 001
6 · The paper itself

Abstract

Cell-mediated immune suppression may play an important role in lung carcinogenesis. We investigated the associations for circulating levels of tryptophan, kynurenine, kynurenine:tryptophan ratio (KTR), quinolinic acid (QA) and neopterin as markers of immune regulation and inflammation with lung cancer risk in 5,364 smoking-matched case-control pairs from 20 prospective cohorts included in the international Lung Cancer Cohort Consortium. All biomarkers were quantified by mass spectrometry-based methods in serum/plasma samples collected on average 6 years before lung cancer diagnosis. Odds ratios (ORs) and 95% confidence intervals (CIs) for lung cancer associated with individual biomarkers were calculated using conditional logistic regression with adjustment for circulating cotinine. Compared to the lowest quintile, the highest quintiles of kynurenine, KTR, QA and neopterin were associated with a 20-30% higher risk, and tryptophan with a 15% lower risk of lung cancer (all p

Indexed as

Adenocarcinoma of LungAdultAgedBiomarkers, TumorCarcinoma, Large CellCarcinoma, Squamous CellCase-Control StudiesFemaleFollow-Up StudiesHumansInflammationKynurenineLung NeoplasmsMaleMiddle AgedNeopterinBiomarkers, TumorKynurenineNeopterinTryptophankynureninelung cancerneopterinquinolinic acidtryptophan

Identifiers

PMID31276202
PMCPMC6960354
OpenAlexW2955948108

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.