ArticleJGH open : an open access journal of gastroenterology and hepatology2019
Reevaluating our understanding of lactulose breath tests by incorporating hydrogen sulfide measurements.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Distinction of meal quality and interaction with the gut microbiota by breath volatilome analysis in humans.Gut microbes · 2026Article
- Substrate-dependent Differences of Colonic Hydrogen Production in a Patient With Fructose Malabsorption.Journal of neurogastroenterology and motility · 2026Article
- Small intestinal microbiome, the underrated maestro of SIMO disease.FEMS microbiology reviews · 2026Review
- Hydrogen Sulfide in Balneology: Physiology, Evidence, and Clinical Translation.International journal of molecular sciences · 2025Review
- The Role of Bacteria-Derived Hydrogen Sulfide in Multiple Axes of Disease.International journal of molecular sciences · 2025Review
- Periodic Changes in the Gut Microbiome in Women with the Mixed Type of Irritable Bowel Syndrome.Biomedicines · 2025Article
- DIAGNOSIS AND TREATMENT OF SMALL INTESTINAL BACTERIAL OVERGROWTH: AN OFFICIAL POSITION PAPER FROM THE BRAZILIAN FEDERATION OF GASTROENTEROLOGY.Arquivos de gastroenterologia · 2025Review
- Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria.Microorganisms · 2024Article
- Detection of PPB-Level HACS sensors · 2024Article
- Miniaturized Capsule System Toward Real-Time Electrochemical Detection of HAdvanced healthcare materials · 2024Article
- Hydrogen Availability Is Dependent on the Actions of Both Hydrogen-Producing and Hydrogen-Consuming Microbes.Digestive diseases and sciences · 2023Article
- Performance and Interpretation of Hydrogen and Methane Breath Testing Impact of North American Consensus Guidelines.Digestive diseases and sciences · 2022Article
- Selective and self-validating breath-level detection of hydrogen sulfide in humid air by gold nanoparticle-functionalized nanotube arrays.Nano research · 2022Article
- Comparing Response of Sheep and Cow Milk on Acute Digestive Comfort and Lactose Malabsorption: A Randomized Controlled Trial in Female Dairy Avoiders.Frontiers in nutrition · 2021Article
- Breath Test Gas Patterns in Inflammatory Bowel Disease with Concomitant Irritable Bowel Syndrome-Like Symptoms: A Controlled Large-Scale Database Linkage Analysis.Digestive diseases and sciences · 2020Article
- Digital Resilience Biomarkers for Personalized Health Maintenance and Disease Prevention.Frontiers in digital health · 2020Review
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Authors and funding
3 authors.
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Abstract
BACKGROUND AND
aimBreath testing has become a commonly used tool in gastroenterology to evaluate changes in the fermentation pattern of the gut microbiome. Currently, hydrogen and methane gas concentrations are measured in breath testing and evaluated against specific cut-off values for interpretation as normal or abnormal. However, microbial gas kinetics is a complex process that is not currently fully considered when interpreting breath gas results. Gas exchange between hydrogen producers and hydrogen consumers (methanogens and sulfate-reducing bacteria) is a process whereby hydrogen availability is determined by both its production and removal. Hydrogen sulfide is a crucial gas involved in this process as it is a major hydrogen-consumptive pathway involved in energy exchange.
methodsThis is a cross-sectional study evaluating lactulose breath testing with the inclusion of hydrogen sulfide measurements in patients referred for breath testing for gastrointestinal symptoms of bloating, excessive gas, and/or abdominal pain.
resultsA total of 159 patients were analyzed between October 2016 and June 2017. Mean hydrogen concentrations with a positive trend through a 3-h period (
conclusionBy incorporating energy exchange in the interpretation of the lactulose breath test, we reevaluated specific breath gas profiles, including those commonly described as "hydrogen nonproducers" and the "double-peak" phenomenon.
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