ArticleMedical research archives2019
Mitochondrial dysfunction in acute kidney injury and sex-specific implications.
Article in Medical research archives, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Association of prognostic nutritional index with risk of contrast induced nephropathy: A meta-analysis.Frontiers in nutrition · 2023Pooled it
- Heart-Brain Temporal Coupling as a Candidate Biomarker of Self-Congruency.Biomedicines · 2026Article
- Mitochondrial SLC3A1 regulates sexual dimorphism in cystinuria.Genes & diseases · 2025Article
- Preventive Effects of Resistance Training on Hemodynamics and Kidney Mitochondrial Bioenergetic Function in Ovariectomized Rats.International journal of molecular sciences · 2024Article
- Sexually dimorphic renal expression of mouse Klotho is directed by a kidney-specific distal enhancer responsive to HNF1b.Communications biology · 2024Article
- Sex bias in prediction and diagnosis of cardiac surgery associated acute kidney injury.BMC nephrology · 2024Observational
- Sex Bias in Prediction and Diagnosis of Cardiac Surgery Associated Acute Kidney Injury.Research square · 2024Article
- Identification of signature genes for renal ischemia‒reperfusion injury based on machine learning and WGCNA.Heliyon · 2023Article
- Benefits of high-intensity interval training compared to continuous training to reduce apoptotic markers in female rats with cisplatin nephrotoxicity - possible modulatory role of IL-11.Apoptosis : an international journal on programmed cell death · 2023Article
- The Activation of cGAS-STING in Acute Kidney Injury.Journal of inflammation research · 2023Review
- Sex Differences of Cardiolipin in Tissue Distribution Based on Targeted Lipidomic Analysis by UHPLC-QTOF-MS/MS.Molecules (Basel, Switzerland) · 2022Article
- Estradiol Ameliorates Acute Kidney Ischemia-Reperfusion Injury by Inhibiting the TGF-βRI-SMAD Pathway.Frontiers in immunology · 2022Article
- Sex-related differences in diabetic kidney disease: A review on the mechanisms and potential therapeutic implications.Journal of diabetes and its complications · 2021Review
- Human antigen R regulates hypoxia-induced mitophagy in renal tubular cells through PARKIN/BNIP3L expressions.Journal of cellular and molecular medicine · 2021Article
- Sex differences in renal mitochondrial function: a hormone-gous opportunity for research.American journal of physiology. Renal physiology · 2020Review
- Gender differences in the susceptibility of hospital-acquired acute kidney injury: more questions than answers.International urology and nephrology · 2020Review
- αInternational journal of molecular sciences · 2020Article
- Frailty in Critical Care Medicine: A Review.Anesthesia and analgesia · 2020Review
- miR-214 represses mitofusin-2 to promote renal tubular apoptosis in ischemic acute kidney injury.American journal of physiology. Renal physiology · 2020Article
- Sex differences in redox homeostasis in renal disease.Redox biology · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The kidney is one of the most energy-demanding organs in the human body, and the maintenance of mitochondrial homeostasis is central to kidney function. Recent advances have led to a greater appreciation of how mitochondrial dysfunction contributes to the pathogenesis of AKI, from decreased ATP production, to enhanced mitochondrial oxidative stress, cell necrosis and apoptosis. Accumulating evidence suggests sexual dimorphism in the response to AKI with males demonstrating greater risk for developing ischemia-reperfusion and sepsis-induced kidney injury. In contrast, females may be more susceptible to nephrotoxic-AKI. There are important sex-related differences in mitochondrial respiration, biogenesis and dynamics that likely contribute to the observed sexual dimorphism in AKI. Sex hormones mediate many of these differences with multiple preclinical studies demonstrating the renoprotective actions of estrogen in many rodent models of AKI. Estrogenic control of mitochondrial biogenesis, function and reactive oxygen species (ROS) generation is discussed. Furthermore, the potential role for sex chromosomes in mediating sex differences in AKI is examined. Novel animal models such as the "four core genotypes" (FCG) mouse model provide us with important tools to study sex chromosome effects in kidney health and disease. By understanding the influences of sexual dimorphism or sex hormones on mitochondrial homeostasis and disease manifestations, we may be able to identify novel therapeutic targets and improve existing treatment options for AKI.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.