Evidence map›Paper›PMID 31275998›Full record

ArticleJournal of immunology research2019

TLR4 Agonist Monophosphoryl Lipid A Alleviated Radiation-Induced Intestinal Injury.

Jiaming Guo, Zhe Liu, Danfeng Zhang, Yuanyuan Chen, Hongran Qin, Tingting Liu, Cong Liu, Jianguo Cui, Bailong Li, Yanyong Yang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Jiaming GuoDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, 800, Xiangyin Road, Shanghai 200433, China.ORCID 0000-0001-9898-237X
Zhe LiuDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, 800, Xiangyin Road, Shanghai 200433, China.
Danfeng ZhangDepartment of Neurosurgery, Changzheng Hospital, Navy Medical University (Second Military Medical University), Shanghai 200003, China.ORCID 0000-0003-2444-9227
Yuanyuan ChenDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, 800, Xiangyin Road, Shanghai 200433, China.ORCID 0000-0002-6142-5913
Hongran QinDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, 800, Xiangyin Road, Shanghai 200433, China.
Tingting LiuDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, 800, Xiangyin Road, Shanghai 200433, China.
Cong LiuDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, 800, Xiangyin Road, Shanghai 200433, China.
Jianguo CuiDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, 800, Xiangyin Road, Shanghai 200433, China.
Bailong LiDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, 800, Xiangyin Road, Shanghai 200433, China.ORCID 0000-0001-5942-2396
Yanyong YangDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, 800, Xiangyin Road, Shanghai 200433, China.ORCID 0000-0002-6882-5274
Jianming CaiDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, 800, Xiangyin Road, Shanghai 200433, China.ORCID 0000-0003-4907-2067
Fu GaoDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, 800, Xiangyin Road, Shanghai 200433, China.ORCID 0000-0002-9792-8248
Second Military Medical University · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The small intestine is one of the most sensitive organs to irradiation injury, and the development of high effective radioprotectants especially with low toxicity for intestinal radiation sickness is urgently needed. Monophosphoryl lipid A (MPLA) was found to be radioprotective in our previous study, while its effect against the intestinal radiation injury remained unknown. In the present study, we firstly determined the intestinal apoptosis after irradiation injury according to the TUNEL assay. Subsequently, we adopted the immunofluorescence technique to assess the expression levels of different biomarkers including Ki67,

Indexed as

AnimalsApoptosisCytokinesDisease Models, AnimalDNA DamageEnteritisInflammation MediatorsIntestinal MucosaLipid AMiceMice, KnockoutRadiation Injuries, ExperimentalRadiation, IonizingToll-Like Receptor 4CytokinesInflammation MediatorsLipid Amonophosphoryl lipid AToll-Like Receptor 4

Identifiers

PMID31275998
PMCPMC6589195
OpenAlexW2948045569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.