Evidence map›Paper›PMID 31275967›Full record

ArticleBioMed research international2019

Atopic Eczema: Genetic Analysis of

Claudia Strafella, Valerio Caputo, Giulietta Minozzi, Filippo Milano, Mauro Arcangeli, Nagat Sobhy, Rania Abdelmaksood, Doaa Hashad, Efstratios Vakirlis, Giuseppe Novelli and 2 more

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Gene variants associated with skin barrier dysfunction in atopic dermatitis: a systematic review and meta-analysis.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2025
    Pooled it
  2. The mRNA levels ofPostepy dermatologii i alergologii · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. RNAseq-Based Prioritization RevealedInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Claudia StrafellaDepartment of Biomedicine and Prevention, Tor Vergata University, via Montpellier 1, 00133, Rome, Italy.ORCID 0000-0003-1334-0920
Valerio CaputoDepartment of Biomedicine and Prevention, Tor Vergata University, via Montpellier 1, 00133, Rome, Italy.
Giulietta MinozziDepartment of Veterinary Medicine (DIMEVET), University of Milan, via Celoria 10, 20100, Milan, Italy.
Filippo MilanoSection of Legal Medicine, Tor Vergata University, via Montpellier 1, 00133, Rome, Italy.
Mauro ArcangeliSection of Legal Medicine, Tor Vergata University, via Montpellier 1, 00133, Rome, Italy.
Nagat SobhyDepartment of Dermatology, Venereology and Andrology, Faculty of Medicine, University of Alexandria, Khartoum Square, Azzaritta, Alexandria, Egypt.
Rania AbdelmaksoodDepartment of Dermatology, Venereology and Andrology, Faculty of Medicine, University of Alexandria, Khartoum Square, Azzaritta, Alexandria, Egypt.
Doaa HashadClinical Pathology, Faculty of Medicine, University of Alexandria, Khartoum Square, Azzaritta, Alexandria, Egypt.
Efstratios VakirlisDepartment of Dermatology and Venereology, Aristotle University Medical School, 124 Delfon Str, 54643, Thessaloniki, Greece.
Giuseppe NovelliDepartment of Biomedicine and Prevention, Tor Vergata University, via Montpellier 1, 00133, Rome, Italy.
Raffaella CascellaDepartment of Biomedicine and Prevention, Tor Vergata University, via Montpellier 1, 00133, Rome, Italy.ORCID 0000-0002-2148-0758
Emiliano GiardinaDepartment of Biomedicine and Prevention, Tor Vergata University, via Montpellier 1, 00133, Rome, Italy.
University of Rome Tor Vergata · ITAlexandria University · EGAristotle University of Thessaloniki · GRUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To date, the genes associated with susceptibility to Atopic Eczema (AE) are mainly implicated in immunity, inflammation, and maintenance of skin barrier. Little is known about the possible relationship between genes modulating Extra-Cellular Matrix (ECM) and AE etiopathogenesis. In this regard, the primary objective of the present study has been the investigation of susceptibility biomarkers localized within genes encoding collagen proteins. Several studies have shown that polymorphisms within the genes encoding such proteins may generate abnormal connective tissues, making them more susceptible to mechanical stress, loss of epidermal integrity, and aging. We therefore decided to investigate three polymorphisms located in

Indexed as

Genetic Predisposition to DiseaseCase-Control StudiesCollagen Type VICollagen Type VIIICollagen Type XDermatitis, AtopicHumansMediterranean RegionPolymorphism, Single NucleotideCOL10A1 protein, humanCOL6A5 protein, humanCol8A1 protein, humanCollagen Type VICollagen Type VIIICollagen Type X

Identifiers

PMID31275967
PMCPMC6582825
OpenAlexW2948667930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.