ArticleFrontiers in medicine2019
Frailty and Intrinsic Capacity: Two Distinct but Related Constructs.
Article in Frontiers in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 134 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Implementation of the Integrated Care of Older People App and ICOPE Monitor in Primary Care (ICOPE)
The Impact of 6-months of Resistance Training on Intrinsic Capacity, Cognition, and Brain/Circulating Biomarkers of Neuroplasticity and Neuroinflammation in Older Adults With Mild Cognitive Impairment: a Randomized Controlled Trial.
Optimizing Prevention of Hospital-acquired Disability Through Integrated Multidomain Interventions: the Age-IT Project
Implementing the National Frailty Policy in Singapore's Primary Care: A Pilot Feasibility Study of The Intrinsic Capacity ProMotion in PrimAry Care for The Frail Program (IMPACTFrail)
Who cites it
134 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prevalence of intrinsic capacity decline among community-dwelling older adults: a systematic review and meta-analysis.Aging clinical and experimental research · 2024Pooled it
- Detection rate of decreased intrinsic capacity of older adults: a systematic review and meta-analysis.Aging clinical and experimental research · 2023Pooled it
- A systematic review of multidomain and lifestyle interventions to support the intrinsic capacity of the older population.Frontiers in medicine · 2022Pooled it
- Correlation of frailty assessment metrics in one-year follow-up of aged care residents: a sub-study of a randomised controlled trial.Aging clinical and experimental research · 2023Trial
- Intergenerational educational mobility and intrinsic capacity in later life: a harmonised analysis of individuals from five countries.Journal of global health · 2026Article
- Frailty and longitudinal pulmonary function trajectories in lung transplant recipients.Respiratory research · 2026Article
- Intrinsic capacity and self-perceived health among home-dwelling older adults: The HUNT study.The Journal of frailty & aging · 2026Article
- Association of Composite and Domain-Specific Intrinsic Capacity and Frailty Among Older Adults in India: Evidence from the Longitudinal Ageing Study in India (LASI).Journal of frailty, sarcopenia and falls · 2026Article
- Rethinking frailty and intrinsic capacity in medical education in Europe through an EAMA student collaboration.European geriatric medicine · 2026Article
- Understanding temporal changes in intrinsic capacity: analysis of domain-specific intrinsic capacity using SHARE data.GeroScience · 2026Article
- A Multidimensional Digital Health Platform to Support Intrinsic Capacity and Healthy Aging: Pilot Feasibility Study.JMIR aging · 2026Article
- Intrinsic capacity and the physical frailty phenotype as complementary predictors of mortality in older Indian adults.Research square · 2026Article
- Burden and Patterns of Oral Diseases and Systemic Comorbidities in Older Adults Attending Primary Care: A Sex- and Age-Stratified Analysis.Medicina (Kaunas, Lithuania) · 2026Article
- Association between intrinsic capacity, genetic predisposition, and risk of venous thromboembolism.Journal of vascular surgery. Venous and lymphatic disorders · 2026Article
- Dual trajectories of intrinsic capacity and frailty: a joint predictor framework for dementia risk in middle-aged and older adults.BMC public health · 2026Article
- Community-dwelling older persons' level of functional ability and heat-related vulnerability: results from the Heat-Health Action Plan study in Cologne, Germany.BMC geriatrics · 2026Article
- Relationship between intrinsic capacity, physical resilience and frailty among older adults patients during stroke recovery: a cross-lagged panel study.BMC geriatrics · 2026Article
- Frailty and intrinsic capacity: integrating complementary concepts to promote healthy ageing and transformation of care.Age and ageing · 2026Review
- Adapting the WHO ICOPE framework to design an integrated frailty and intrinsic capacity management community-based programme in Singapore: a programme description using the updated and modified TIDieR checklist.BMC health services research · 2026Article
- Diagnostic accuracy of the World Health Organization ICOPE screening tool in Brazilian older adults: a cross-sectional study.Clinics (Sao Paulo, Brazil) · 2026Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frailty is a clinical condition characterized by the individual's increased vulnerability to endogenous and exogenous stressors. It is determined by the reduction of homeostatic capacities of the organism and responsible for a marked risk of adverse health outcomes (including functional loss and mortality). Frailty originates from the geriatric background and may pave the way toward a model of care centered on the person, deviating from the traditional and obsolete disease-focused approach. Unfortunately, many controversies have affected the field of frailty over the years and ambiguities have been growing. In particular, the common use of frailty as condition to "exclude" from interventions is a worrisome trend. In fact, the detection of frailty should instead represent the entry point for a more in-depth analysis with the aim of identifying the causes of individual's increased vulnerability and implementing a person-tailored intervention plan. With the aim of promoting a more comprehensive and appropriate assessment of the aging population, the World Health Organization introduced the concept of intrinsic capacity (IC), defined as the composite of all physical and mental capacities that an individual can draw upon during his/her life. Frailty and IC are two constructs stemming from the same need of overcoming traditional medical paradigms that negatively impact on the correct way clinical and research practice should be conducted in older persons. In this article, we describe the similarities and differences between the two constructs, highlighting how geriatric medicine contributed to their development and will be crucial for their further integration in future healthcare models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.