ArticleCardiovascular diagnosis and therapy2019
Prevalence and impact of non-cardiovascular comorbidities among older adults hospitalized for non-ST segment elevation acute coronary syndrome.
Article in Cardiovascular diagnosis and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multimorbidity in Patients With Acute Coronary Syndrome Is Associated With Greater Mortality, Higher Readmission Rates, and Increased Length of Stay: A Systematic Review.The Journal of cardiovascular nursingPooled it
- Article
- Prognostic Relevance of Type 4a Myocardial Infarction and Periprocedural Myocardial Injury in Patients With Non-ST-Segment-Elevation Myocardial Infarction.Circulation · 2025Article
- Revascularization strategies in Non-ST segment elevation myocardial infarction: the clash continues.Frontiers in cardiovascular medicine · 2025Review
- Common non-cardiovascular multimorbidity groupings and clinical outcomes in older adults with major cardiovascular disease.Journal of the American Geriatrics Society · 2023Article
- Prognostic Impact of Non-Cardiac Comorbidities on Long-Term Prognosis in Patients with Reduced and Preserved Ejection Fraction following Acute Myocardial Infarction.Journal of personalized medicine · 2023Article
- Effects of medical insurance system on the hospitalization cost of acute myocardial infarction patients.Cost effectiveness and resource allocation : C/E · 2022Article
- Association between α1-antitrypsin and acute coronary syndrome.Experimental and therapeutic medicine · 2020Article
- Association of comorbidities with clinical outcomes in patients after acute myocardial infarction.International journal of cardiology. Heart & vasculature · 2020Article
- Observational
- Impact of Different Geriatric Conditions on Choice of Therapy and In-Hospital Outcomes in Elderly Patients with Acute Coronary Syndrome.Clinical interventions in aging · 2020Article
- Optimization of multi-organ failure for successful coronary angioplasty in acute myocardial infarction after pneumonectomy.American journal of cardiovascular disease · 2020Article
- Trends in the magnitude of chronic conditions in patients hospitalized with a first acute myocardial infarction.Journal of multimorbidity and comorbidityArticle
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9 authors.
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Abstract
backgroundThere is a paucity of information on the prognostic importance of non-cardiovascular comorbidities (NCCs) among patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). This study examined the prevalence and impact of NCCs on the length of stay (LOS) and mortality among older adults hospitalized for NSTE-ACS.
methodsAmong 1,488 older adults (mean age 79.4±8.4 years; 62.0% male) hospitalized for NSTE-ACS at a tertiary hospital in Melbourne, Australia, during 2013-2015, we collected data on comorbidities, LOS, and discharge outcomes. Thirteen NCCs were studied. Negative binomial and Cox proportional regression models were applied to examine the association between NCCs and LOS and in-hospital death, respectively.
resultsApproximately 53% of the patients had ≥1 NCCs. Diabetes and renal disease as well as anemia and renal disease co-existed more frequently than expected. Compared to having no NCCs, having one NCC was not associated with a significant increase in the likelihood of longer LOS [incidence rate ratio (IRR) 1.07; 95% CI: 0.99-1.15; P=0.085] or in-hospital death [hazard ratio (HR) 1.11; 95% CI: 0.65-1.90; P=0.707]. However, having ≥2 NCCs was associated with 22% and 79% increased likelihood of longer LOS (IRR 1.22, 95% CI: 1.11-1.33; P<0.001) and in-hospital death (HR 1.79, 95% CI: 1.06-3.03; P=0.029), respectively, compared to not having any NCC. Certain NCC dyads [e.g., chronic pulmonary disease (CPD) + renal disease] exhibited multiplicative effect such that their impact on patients' LOS or survival exceeded the sum of the individual effects of the component NCCs.
conclusionsOver half of older patients hospitalized with NSTE-ACS had NCCs. A higher burden of NCCs correlated with increased LOS and lower survival. Contemporary ACS management guidelines need to recognize and incorporate protocols for the treatment of individuals with multiple chronic conditions to reduce the occurrence of adverse outcomes.
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